Frontiers in optical imaging of cerebral blood flow and metabolism

Anna Devor, Sava Sakadžić, Vivek Srinivasan, Mohammad A. Yaseen, Krystal Nizar, Payam A. Saisan, Peifang Tian, Anders M. Dale, Sergei A. Vinogradov, Maria Angela Franceschini, David A. Boas

Research output: Contribution to journalReview articlepeer-review

111 Scopus citations


In vivo optical imaging of cerebral blood flow (CBF) and metabolism did not exist 50 years ago. While point optical fluorescence and absorption measurements of cellular metabolism and hemoglobin concentrations had already been introduced by then, point blood flow measurements appeared only 40 years ago. The advent of digital cameras has significantly advanced two-dimensional optical imaging of neuronal, metabolic, vascular, and hemodynamic signals. More recently, advanced laser sources have enabled a variety of novel three-dimensional high-spatial-resolution imaging approaches. Combined, as we discuss here, these methods are permitting a multifaceted investigation of the local regulation of CBF and metabolism with unprecedented spatial and temporal resolution. Through multimodal combination of these optical techniques with genetic methods of encoding optical reporter and actuator proteins, the future is bright for solving the mysteries of neurometabolic and neurovascular coupling and translating them to clinical utility.

Original languageEnglish (US)
Pages (from-to)1259-1276
Number of pages18
JournalJournal of Cerebral Blood Flow and Metabolism
Issue number7
StatePublished - Jul 1 2012
Externally publishedYes


  • Energy metabolism
  • hemodynamic
  • homeostasis
  • in vivo imaging
  • neurovascular

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Clinical Neurology
  • Neurology


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