Frontal motor cortex activity during reactive control is associated with past suicidal behavior in recent-onset schizophrenia

Michael J. Minzenberg, Tyler Lesh, Tara A Niendam, Jong H. Yoon, Yaoan Cheng, Remy N. Rhoades, Cameron S Carter

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: Suicide is prevalent in schizophrenia (SZ), yet the neural system functions that confer suicide risk remain obscure. Circuits operated by the prefrontal cortex (PFC) are altered in SZ, including those that support reactive control, and PFC changes are observed in postmortem studies of heterogeneous suicide victims. Aims: We tested whether history of suicide attempt is associated with altered frontal motor cortex activity during reactive control processes. Method: We evaluated 17 patients with recent onset of DSM-IV-TR-defined SZ using the Columbia Suicide Severity Rating Scale and functional magnetic resonance imaging during Stroop task performance. Group-level regression models relating past suicidal behavior to frontal activation controlled for depression, psychosis, and impulsivity. Results: Past suicidal behavior was associated with relatively higher activation in the left-hemisphere supplementary motor area (SMA), pre-SMA, premotor cortex, and dorsolateral PFC, all ipsilateral to the active primary motor cortex. Conclusion: This study provides unique evidence that suicidal behavior in patients with recent-onset SZ directly relates to frontal motor cortex activity during reactive control, in a pattern reciprocal to the relationship with proactive control found previously. Further work should address how frontal-based control functions change with risk over time, and their potential utility as a biomarker for interventions to mitigate suicide risk in SZ.

Original languageEnglish (US)
Pages (from-to)363-370
Number of pages8
JournalCrisis
Volume36
Issue number5
DOIs
StatePublished - 2015

Fingerprint

Motor Cortex
Frontal Lobe
Suicide
Schizophrenia
Motor Activity
Prefrontal Cortex
Impulsive Behavior
Task Performance and Analysis
Diagnostic and Statistical Manual of Mental Disorders
Psychotic Disorders
Biomarkers
Magnetic Resonance Imaging
Depression

Keywords

  • Cognitive control
  • fMRI
  • Prefrontal cortex
  • Schizophrenia
  • Suicide

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Frontal motor cortex activity during reactive control is associated with past suicidal behavior in recent-onset schizophrenia. / Minzenberg, Michael J.; Lesh, Tyler; Niendam, Tara A; Yoon, Jong H.; Cheng, Yaoan; Rhoades, Remy N.; Carter, Cameron S.

In: Crisis, Vol. 36, No. 5, 2015, p. 363-370.

Research output: Contribution to journalArticle

Minzenberg, Michael J. ; Lesh, Tyler ; Niendam, Tara A ; Yoon, Jong H. ; Cheng, Yaoan ; Rhoades, Remy N. ; Carter, Cameron S. / Frontal motor cortex activity during reactive control is associated with past suicidal behavior in recent-onset schizophrenia. In: Crisis. 2015 ; Vol. 36, No. 5. pp. 363-370.
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abstract = "Background: Suicide is prevalent in schizophrenia (SZ), yet the neural system functions that confer suicide risk remain obscure. Circuits operated by the prefrontal cortex (PFC) are altered in SZ, including those that support reactive control, and PFC changes are observed in postmortem studies of heterogeneous suicide victims. Aims: We tested whether history of suicide attempt is associated with altered frontal motor cortex activity during reactive control processes. Method: We evaluated 17 patients with recent onset of DSM-IV-TR-defined SZ using the Columbia Suicide Severity Rating Scale and functional magnetic resonance imaging during Stroop task performance. Group-level regression models relating past suicidal behavior to frontal activation controlled for depression, psychosis, and impulsivity. Results: Past suicidal behavior was associated with relatively higher activation in the left-hemisphere supplementary motor area (SMA), pre-SMA, premotor cortex, and dorsolateral PFC, all ipsilateral to the active primary motor cortex. Conclusion: This study provides unique evidence that suicidal behavior in patients with recent-onset SZ directly relates to frontal motor cortex activity during reactive control, in a pattern reciprocal to the relationship with proactive control found previously. Further work should address how frontal-based control functions change with risk over time, and their potential utility as a biomarker for interventions to mitigate suicide risk in SZ.",
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