Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts

Bruce R Reed, J. L. Eberling, Dan M Mungas, M. Weiner, W. J. Jagust

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Background: A proportion of patients with subcortical lacunes will suffer progressive cognitive dysfunction, but the basis for this decline is controversial and little is known about predicting cognitive decline in these patients. Studies of Alzheimer disease have shown that imaging measures of temporal and parietal metabolism and blood flow predict disease course. Objective: To determine whether regional cerebral glucose metabolism predicts cognitive decline by testing 2 opposing hypotheses: (1) temporoparietal activity predicts decline (based on the idea that concomitant Alzheimer disease causes decline) vs (2) frontal hypometabolism predicts decline (based on evidence that subcortical frontal circuits are especially vulnerable to small vessel ischemia). Design: Prospective cohort study. Setting: University outpatient dementia center. Patients: A convenience sample of 26 patients with radiologically defined lacunes and baseline cognitive function ranging from normal to moderately demented. Main Outcome Measures: Regional cerebral metabolism was quantitated in the form of atrophy-corrected positron emission tomographic activity ratios in cortical regions that were defined a priori. Patients were followed up at a mean of 1.8 years, and the dependent variable was rate of change in the Mini-Mental State Examination score. Results: Bilateral and right hemisphere dorsolateral frontal metabolism significantly predicted cognitive decline, with right dorsolateral frontal metabolism explaining 19% of the variance. No other positron emission tomographic region was a significant predictor, nor were demographic variables or baseline Mini-Mental State Examination scores significant predictors. Conclusion: Cognitive decline in patients with lacunes may result in part from progressive vascular compromise in subcortical frontal circuits.

Original languageEnglish (US)
Pages (from-to)493-497
Number of pages5
JournalArchives of Neurology
Volume58
Issue number3
StatePublished - 2001

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Lacunar Stroke
Frontal Lobe
Alzheimer Disease
Electrons
Cognition
Atrophy
Blood Vessels
Dementia
Cognitive Dysfunction
Cohort Studies
Outpatients
Ischemia
Demography
Outcome Assessment (Health Care)
Prospective Studies
Glucose
Metabolism

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts. / Reed, Bruce R; Eberling, J. L.; Mungas, Dan M; Weiner, M.; Jagust, W. J.

In: Archives of Neurology, Vol. 58, No. 3, 2001, p. 493-497.

Research output: Contribution to journalArticle

Reed, Bruce R ; Eberling, J. L. ; Mungas, Dan M ; Weiner, M. ; Jagust, W. J. / Frontal lobe hypometabolism predicts cognitive decline in patients with lacunar infarcts. In: Archives of Neurology. 2001 ; Vol. 58, No. 3. pp. 493-497.
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