TY - JOUR
T1 - From cleanroom to desktop
T2 - Emerging micro-nanofabrication technology for biomedical applications
AU - Pan, Tingrui
AU - Wang, Wei
PY - 2011/2/1
Y1 - 2011/2/1
N2 - This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities.
AB - This review is motivated by the growing demand for low-cost, easy-to-use, compact-size yet powerful micro-nanofabrication technology to address emerging challenges of fundamental biology and translational medicine in regular laboratory settings. Recent advancements in the field benefit considerably from rapidly expanding material selections, ranging from inorganics to organics and from nanoparticles to self-assembled molecules. Meanwhile a great number of novel methodologies, employing off-the-shelf consumer electronics, intriguing interfacial phenomena, bottom-up self-assembly principles, etc., have been implemented to transit micro-nanofabrication from a cleanroom environment to a desktop setup. Furthermore, the latest application of micro-nanofabrication to emerging biomedical research will be presented in detail, which includes point-of-care diagnostics, on-chip cell culture as well as bio-manipulation. While significant progresses have been made in the rapidly growing field, both apparent and unrevealed roadblocks will need to be addressed in the future. We conclude this review by offering our perspectives on the current technical challenges and future research opportunities.
KW - Biomedical engineering
KW - Lithography
KW - Microfabrication
KW - Nanofabrication
KW - Out-of-cleanroom
UR - http://www.scopus.com/inward/record.url?scp=79951557320&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79951557320&partnerID=8YFLogxK
U2 - 10.1007/s10439-010-0218-9
DO - 10.1007/s10439-010-0218-9
M3 - Article
C2 - 21161384
AN - SCOPUS:79951557320
VL - 39
SP - 600
EP - 620
JO - Annals of Biomedical Engineering
JF - Annals of Biomedical Engineering
SN - 0090-6964
IS - 2
ER -