From bench to bedside: Stealth of enteroinvasive pathogens

Research output: Contribution to journalArticle

101 Scopus citations

Abstract

Bacterial enteric infections are often associated with diarrhoea or vomiting, which are clinical presentations commonly referred to as gastroenteritis. However, some enteric pathogens, including typhoidal Salmonella serotypes, Brucella species and enteropathogenic Yersinia species are associated with a clinical syndrome that is characterized by abdominal pain and/or fever and is distinct from acute gastroenteritis. Recent insights into molecular mechanisms of the host-pathogen interaction show that these enteric pathogens share important characteristics that explain why the initial host responses associated with these agents more closely resemble host responses to viral or parasitic infections. Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside.

Original languageEnglish (US)
Pages (from-to)883-892
Number of pages10
JournalNature Reviews Microbiology
Volume6
Issue number12
DOIs
StatePublished - 2008

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Fingerprint Dive into the research topics of 'From bench to bedside: Stealth of enteroinvasive pathogens'. Together they form a unique fingerprint.

  • Cite this