From bench to bedside: Stealth of enteroinvasive pathogens

Research output: Contribution to journalArticle

97 Citations (Scopus)

Abstract

Bacterial enteric infections are often associated with diarrhoea or vomiting, which are clinical presentations commonly referred to as gastroenteritis. However, some enteric pathogens, including typhoidal Salmonella serotypes, Brucella species and enteropathogenic Yersinia species are associated with a clinical syndrome that is characterized by abdominal pain and/or fever and is distinct from acute gastroenteritis. Recent insights into molecular mechanisms of the host-pathogen interaction show that these enteric pathogens share important characteristics that explain why the initial host responses associated with these agents more closely resemble host responses to viral or parasitic infections. Host responses contribute to the clinical presentation of disease and improved understanding of these responses in the laboratory is beginning to bridge the gap between bench and bedside.

Original languageEnglish (US)
Pages (from-to)883-892
Number of pages10
JournalNature Reviews Microbiology
Volume6
Issue number12
DOIs
StatePublished - 2008

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Gastroenteritis
Host-Pathogen Interactions
Yersinia
Brucella
Parasitic Diseases
Virus Diseases
Bacterial Infections
Salmonella
Abdominal Pain
Vomiting
Diarrhea
Fever
Serogroup

ASJC Scopus subject areas

  • Immunology and Microbiology(all)

Cite this

From bench to bedside : Stealth of enteroinvasive pathogens. / Tsolis, Renee M; Young, Glenn M.; Solnick, Jay V; Baumler, Andreas J.

In: Nature Reviews Microbiology, Vol. 6, No. 12, 2008, p. 883-892.

Research output: Contribution to journalArticle

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