From bead to flask: Synthesis of a complex β-amido-amide for probe-development studies

Kevin S. Martin, Cristian Soldi, Kellan N. Candee, Hiromi I. Wettersten, Robert H Weiss, Jared T. Shaw

Research output: Contribution to journalArticlepeer-review


A concise synthesis of benzimidazole-substituted β-amido-amide LLW62 is presented. The original synthesis of compounds related to LLW62 was developed on Rink resin as part of a "one-bead, one-compound" combinatorial approach for on-bead screening purposes. The current synthesis is carried out in solution and is amenable to scale-up for follow-up studies on LLW62 and investigations of related structures. The key step involves the use of a β-amino acid-forming three-component reaction (3CR), the scope of which defines its role in the synthetic strategy.

Original languageEnglish (US)
Pages (from-to)260-264
Number of pages5
JournalBeilstein Journal of Organic Chemistry
StatePublished - Feb 6 2013


  • β-amino acid
  • Benzimidazole
  • Multicomponent reaction

ASJC Scopus subject areas

  • Organic Chemistry

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