Frictionless sliding of single-stranded DNA in a carbon nanotube pore observed by single molecule force spectroscopy

Valentin Lulevich; Sangil Kim; Costas P. Grigoropoulos; Aleksandr Noy

doi:10.1021/nl104116s

Frictionless sliding of single-stranded DNA in a carbon nanotube pore observed by single molecule force spectroscopy

Valentin Lulevich, Sangil Kim, Costas P. Grigoropoulos, Aleksandr Noy

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Smooth inner pores of carbon nanotubes (CNT) provide a fascinating model for studying biological transport. We used an atomic force microscope to pull a single-stranded DNA oligomer from a carbon nanotube pore. DNA extraction from CNT pores occurs at a nearly constant force, which is drastically different from the elastic profile commonly observed during polymer stretching with atomic force microscopy. We show that a combination of the frictionless nanotube pore walls and an unfavorable DNA solvation energy produces this constant force profiles.

Original language	English (US)
Pages (from-to)	1171-1176
Number of pages	6
Journal	Nano Letters
Volume	11
Issue number	3
DOIs	https://doi.org/10.1021/nl104116s
State	Published - Mar 9 2011
Externally published	Yes

Keywords

carbon nanotubes
CNT membrane
DNA
molecular friction
nanofluidics
Single molecule force spectroscopy

ASJC Scopus subject areas

Condensed Matter Physics
Bioengineering
Chemistry(all)
Materials Science(all)
Mechanical Engineering

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10.1021/nl104116s

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abstract = "Smooth inner pores of carbon nanotubes (CNT) provide a fascinating model for studying biological transport. We used an atomic force microscope to pull a single-stranded DNA oligomer from a carbon nanotube pore. DNA extraction from CNT pores occurs at a nearly constant force, which is drastically different from the elastic profile commonly observed during polymer stretching with atomic force microscopy. We show that a combination of the frictionless nanotube pore walls and an unfavorable DNA solvation energy produces this constant force profiles.",

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AU - Lulevich, Valentin

AU - Kim, Sangil

AU - Grigoropoulos, Costas P.

AU - Noy, Aleksandr

PY - 2011/3/9

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N2 - Smooth inner pores of carbon nanotubes (CNT) provide a fascinating model for studying biological transport. We used an atomic force microscope to pull a single-stranded DNA oligomer from a carbon nanotube pore. DNA extraction from CNT pores occurs at a nearly constant force, which is drastically different from the elastic profile commonly observed during polymer stretching with atomic force microscopy. We show that a combination of the frictionless nanotube pore walls and an unfavorable DNA solvation energy produces this constant force profiles.

AB - Smooth inner pores of carbon nanotubes (CNT) provide a fascinating model for studying biological transport. We used an atomic force microscope to pull a single-stranded DNA oligomer from a carbon nanotube pore. DNA extraction from CNT pores occurs at a nearly constant force, which is drastically different from the elastic profile commonly observed during polymer stretching with atomic force microscopy. We show that a combination of the frictionless nanotube pore walls and an unfavorable DNA solvation energy produces this constant force profiles.

KW - carbon nanotubes

KW - CNT membrane

KW - DNA

KW - molecular friction

KW - nanofluidics

KW - Single molecule force spectroscopy

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