FRET-like fluorophore-nanoparticle complex for highly specific cancer localization

Jianting Wang, Michael H. Nantz, Samuel Achilefu, Kyung A. Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Citations (Scopus)

Abstract

Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages407-413
Number of pages7
Volume662
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume662
ISSN (Print)00652598

Fingerprint

Fluorophores
Nanoparticles
Fluorescence
Neoplasms
Molecular Imaging
Molecular imaging
Quantum yield
Breast Neoplasms
Quenching

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Wang, J., Nantz, M. H., Achilefu, S., & Kang, K. A. (2010). FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. In Advances in Experimental Medicine and Biology (Vol. 662, pp. 407-413). (Advances in Experimental Medicine and Biology; Vol. 662). https://doi.org/10.1007/978-1-4419-1241-1_59

FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. / Wang, Jianting; Nantz, Michael H.; Achilefu, Samuel; Kang, Kyung A.

Advances in Experimental Medicine and Biology. Vol. 662 2010. p. 407-413 (Advances in Experimental Medicine and Biology; Vol. 662).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Wang, J, Nantz, MH, Achilefu, S & Kang, KA 2010, FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. in Advances in Experimental Medicine and Biology. vol. 662, Advances in Experimental Medicine and Biology, vol. 662, pp. 407-413. https://doi.org/10.1007/978-1-4419-1241-1_59
Wang J, Nantz MH, Achilefu S, Kang KA. FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. In Advances in Experimental Medicine and Biology. Vol. 662. 2010. p. 407-413. (Advances in Experimental Medicine and Biology). https://doi.org/10.1007/978-1-4419-1241-1_59
Wang, Jianting ; Nantz, Michael H. ; Achilefu, Samuel ; Kang, Kyung A. / FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. Advances in Experimental Medicine and Biology. Vol. 662 2010. pp. 407-413 (Advances in Experimental Medicine and Biology).
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