FRET-like fluorophore-nanoparticle complex for highly specific cancer localization

Jianting Wang, Michael H. Nantz, Samuel Achilefu, Kyung A. Kang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

4 Scopus citations

Abstract

Fluorophore mediated bio-signal retrieval has been extensively used in molecular imaging. However, only a limited number of fluorophores can be used for humans and their quantum yield is usually low. Another important issue is emitting fluorescence at the disease site, with a minimal non-specific emission at any other sites. Artificial quenching and enhancing of fluorescence was found to be possible by manipulating the distance between a fluorophore and a certain type of nanometal particle. Utilizing this unique property, we have designed a novel, FRET-like, fluorophore-nanoparticle complex. The complex emits fluorescence conditionally only at a disease site at an enhanced level. As a model system, our complex is designed to target breast cancer. As an initial step for developing this cancer locator, fluorescence alteration was studied when a spacer at various lengths is placed between a nanogold particle and a safe fluorophore.

Original languageEnglish (US)
Title of host publicationAdvances in Experimental Medicine and Biology
Pages407-413
Number of pages7
Volume662
DOIs
StatePublished - 2010
Externally publishedYes

Publication series

NameAdvances in Experimental Medicine and Biology
Volume662
ISSN (Print)00652598

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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    Wang, J., Nantz, M. H., Achilefu, S., & Kang, K. A. (2010). FRET-like fluorophore-nanoparticle complex for highly specific cancer localization. In Advances in Experimental Medicine and Biology (Vol. 662, pp. 407-413). (Advances in Experimental Medicine and Biology; Vol. 662). https://doi.org/10.1007/978-1-4419-1241-1_59