Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders

Ariane H. Ayer, Kevin Wojta, Eliana Marisa Ramos, Deepika Dokuru, Jason A. Chen, Anna M. Karydas, John D. Papatriantafyllou, Dimitrios Agiomyrgiannakis, Vasiliki Kamtsadeli, Niki Tsinia, Dimitra Sali, Karen H. Gylys, Federica Agosta, Massimo Filippi, Gary W. Small, David A. Bennett, Marla Gearing, Jorge L. Juncos, Joel Kramer, Suzee E. LeeJennifer S. Yokoyama, Mario F. Mendez, Helena Chui, Chris Zarow, John M. Ringman, Ulkan Kilic, Gülsen Babacan-Yildiz, Allan Levey, Charles S. Decarli, Carl W. Cotman, Adam L. Boxer, Bruce L. Miller, Giovanni Coppola

Research output: Contribution to journalArticle

Abstract

Objective:A rare variant in TREM2 (p.R47H, rs75932628) has been consistently reported to increase the risk for Alzheimer disease (AD), while mixed evidence has been reported for association of the variant with other neurodegenerative diseases. Here, we investigated the frequency of the R47H variant in a diverse and well-characterized multicenter neurodegenerative disease cohort.Methods:We examined the frequency of the R47H variant in a diverse neurodegenerative disease cohort, including a total of 3058 patients clinically diagnosed with AD, frontotemporal dementia spectrum syndromes, mild cognitive impairment, progressive supranuclear palsy syndrome, corticobasal syndrome, or amyotrophic lateral sclerosis and 5089 control subjects.Results:We observed a significant association between the R47H variant and AD, while no association was observed with any other neurodegenerative disease included in this study.Conclusions:Our results support the consensus that the R47H variant is significantly associated with AD. However, we did not find evidence for association of the R47H variant with other neurodegenerative diseases.

Original languageEnglish (US)
Pages (from-to)327-330
Number of pages4
JournalAlzheimer disease and associated disorders
Volume33
Issue number4
DOIs
StatePublished - Jan 1 2019

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Keywords

  • Alzheimer disease
  • amyotrophic lateral sclerosis
  • association study
  • corticobasal syndrome
  • frontotemporal dementia
  • genetics
  • mild cognitive impairment
  • progressive supranuclear palsy
  • TREM2

ASJC Scopus subject areas

  • Clinical Psychology
  • Gerontology
  • Geriatrics and Gerontology
  • Psychiatry and Mental health

Cite this

Ayer, A. H., Wojta, K., Ramos, E. M., Dokuru, D., Chen, J. A., Karydas, A. M., Papatriantafyllou, J. D., Agiomyrgiannakis, D., Kamtsadeli, V., Tsinia, N., Sali, D., Gylys, K. H., Agosta, F., Filippi, M., Small, G. W., Bennett, D. A., Gearing, M., Juncos, J. L., Kramer, J., ... Coppola, G. (2019). Frequency of the TREM2 R47H Variant in Various Neurodegenerative Disorders. Alzheimer disease and associated disorders, 33(4), 327-330. https://doi.org/10.1097/WAD.0000000000000339