Frequency of deletion formation decreases exponentially with distance between short direct repeats

Frederic Chedin, E. Dervyn, R. Dervyn, S. D. Ehrlich, P. Noirot

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000‐fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA‐duplex flexibility. A similar relationship between deletion formation and distance was observed in a θ‐replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalMolecular Microbiology
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

Fingerprint

Nucleic Acid Repetitive Sequences
Bacillus subtilis
Plasmids
Chromosomes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

Cite this

Frequency of deletion formation decreases exponentially with distance between short direct repeats. / Chedin, Frederic; Dervyn, E.; Dervyn, R.; Ehrlich, S. D.; Noirot, P.

In: Molecular Microbiology, Vol. 12, No. 4, 01.01.1994, p. 561-569.

Research output: Contribution to journalArticle

Chedin, Frederic ; Dervyn, E. ; Dervyn, R. ; Ehrlich, S. D. ; Noirot, P. / Frequency of deletion formation decreases exponentially with distance between short direct repeats. In: Molecular Microbiology. 1994 ; Vol. 12, No. 4. pp. 561-569.
@article{4477ff577dc44ad6aad0be5dbc7afe0f,
title = "Frequency of deletion formation decreases exponentially with distance between short direct repeats",
abstract = "The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000‐fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA‐duplex flexibility. A similar relationship between deletion formation and distance was observed in a θ‐replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.",
author = "Frederic Chedin and E. Dervyn and R. Dervyn and Ehrlich, {S. D.} and P. Noirot",
year = "1994",
month = "1",
day = "1",
doi = "10.1111/j.1365-2958.1994.tb01042.x",
language = "English (US)",
volume = "12",
pages = "561--569",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
number = "4",

}

TY - JOUR

T1 - Frequency of deletion formation decreases exponentially with distance between short direct repeats

AU - Chedin, Frederic

AU - Dervyn, E.

AU - Dervyn, R.

AU - Ehrlich, S. D.

AU - Noirot, P.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000‐fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA‐duplex flexibility. A similar relationship between deletion formation and distance was observed in a θ‐replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

AB - The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000‐fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA‐duplex flexibility. A similar relationship between deletion formation and distance was observed in a θ‐replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

UR - http://www.scopus.com/inward/record.url?scp=0028307745&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028307745&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2958.1994.tb01042.x

DO - 10.1111/j.1365-2958.1994.tb01042.x

M3 - Article

C2 - 7934879

AN - SCOPUS:0028307745

VL - 12

SP - 561

EP - 569

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 4

ER -