Frequency of deletion formation decreases exponentially with distance between short direct repeats

Frederic Chedin, E. Dervyn, R. Dervyn, S. D. Ehrlich, P. Noirot

Research output: Contribution to journalArticle

68 Scopus citations

Abstract

The effect of distance between 18 bp direct repeats on deletion formation has been examined in Bacillus subtilis. The deletion frequency decreased exponentially by more than 1000‐fold as the distance increased from 33 to 2313 bp. This decrease occurred in two distinct phases, which may be determined by DNA‐duplex flexibility. A similar relationship between deletion formation and distance was observed in a θ‐replicating plasmid and in the chromosome, indicating that this relationship might have a general validity.

Original languageEnglish (US)
Pages (from-to)561-569
Number of pages9
JournalMolecular Microbiology
Volume12
Issue number4
DOIs
StatePublished - Jan 1 1994
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology

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