Frequency dependent effects of oscillating fluid flow on bone cells

Jun You; Marnie Saunders; Clare E Yellowley-genetos; Henry Donahue; Christopher Jacobs

Frequency dependent effects of oscillating fluid flow on bone cells

Jun You, Marnie Saunders, Clare E Yellowley-genetos, Henry Donahue, Christopher Jacobs

Research output: Contribution to journal › Article › peer-review

Abstract

A high-frequency flow device was developed to deliver a wide range of sinusoidally oscillating flow frequencies while monitoring real time [ Ca2+]i and PGE2 production in MC3T3-E1 osteoblastic cells. Results show that the more stimulatory frequency for [Ca2+]i was 0.1 Hz. However, 0.5-1.0 Hz was more stimulatory of PGE2 production. This suggests that the signaling pathways for [Ca2+]i and PGE2 may be different. Moreover considering viscoelastic properties of cells, results suggest that bone cell [ Ca2+]i response is more dependent on cell membrane deformation whereas PGE2 production is more related to cytosol internal friction.

Original language	English (US)
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Externally published	Yes

ASJC Scopus subject areas

Biomedical Engineering

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abstract = "A high-frequency flow device was developed to deliver a wide range of sinusoidally oscillating flow frequencies while monitoring real time [ Ca2+]i and PGE2 production in MC3T3-E1 osteoblastic cells. Results show that the more stimulatory frequency for [Ca2+]i was 0.1 Hz. However, 0.5-1.0 Hz was more stimulatory of PGE2 production. This suggests that the signaling pathways for [Ca2+]i and PGE2 may be different. Moreover considering viscoelastic properties of cells, results suggest that bone cell [ Ca2+]i response is more dependent on cell membrane deformation whereas PGE2 production is more related to cytosol internal friction.",

author = "Jun You and Marnie Saunders and Yellowley-genetos, {Clare E} and Henry Donahue and Christopher Jacobs",

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AU - You, Jun

AU - Saunders, Marnie

AU - Yellowley-genetos, Clare E

AU - Donahue, Henry

AU - Jacobs, Christopher

PY - 2000

Y1 - 2000

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AB - A high-frequency flow device was developed to deliver a wide range of sinusoidally oscillating flow frequencies while monitoring real time [ Ca2+]i and PGE2 production in MC3T3-E1 osteoblastic cells. Results show that the more stimulatory frequency for [Ca2+]i was 0.1 Hz. However, 0.5-1.0 Hz was more stimulatory of PGE2 production. This suggests that the signaling pathways for [Ca2+]i and PGE2 may be different. Moreover considering viscoelastic properties of cells, results suggest that bone cell [ Ca2+]i response is more dependent on cell membrane deformation whereas PGE2 production is more related to cytosol internal friction.

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