Abstract
Freeze-fracture studies were conducted in erythrocyte plasma membrane from 8 patients with Duchenne muscular dystrophy (DMD), 8 age-matched controls, 3 adults controls, 10 patients with myotonic muscular dystrophy, and 26 other neuromuscular disease controls. There was marked depletion of intramembranous particles in Duchenne dystrophy, whereas intramembranous particle density counts in other neuromuscular diseases were within normal limits. Therefore, the internal molecular architecture of the erythrocyte membrane is abnormal in Duchenne dystrophy, supporting the concept that a membrane defect involving multiple tissues is present in this disorder.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 670-675 |
| Number of pages | 6 |
| Journal | Neurology |
| Volume | 29 |
| Issue number | 5 |
| State | Published - 1979 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Neuroscience(all)
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Freeze-fracture studies of erythrocyte plasma membrane in human neuromuscular diseases. / Wakayama, Y.; Hodson, A.; Bonilla, E.; Pleasure, David E; Schotland, D. L.
In: Neurology, Vol. 29, No. 5, 1979, p. 670-675.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Freeze-fracture studies of erythrocyte plasma membrane in human neuromuscular diseases
AU - Wakayama, Y.
AU - Hodson, A.
AU - Bonilla, E.
AU - Pleasure, David E
AU - Schotland, D. L.
PY - 1979
Y1 - 1979
N2 - Freeze-fracture studies were conducted in erythrocyte plasma membrane from 8 patients with Duchenne muscular dystrophy (DMD), 8 age-matched controls, 3 adults controls, 10 patients with myotonic muscular dystrophy, and 26 other neuromuscular disease controls. There was marked depletion of intramembranous particles in Duchenne dystrophy, whereas intramembranous particle density counts in other neuromuscular diseases were within normal limits. Therefore, the internal molecular architecture of the erythrocyte membrane is abnormal in Duchenne dystrophy, supporting the concept that a membrane defect involving multiple tissues is present in this disorder.
AB - Freeze-fracture studies were conducted in erythrocyte plasma membrane from 8 patients with Duchenne muscular dystrophy (DMD), 8 age-matched controls, 3 adults controls, 10 patients with myotonic muscular dystrophy, and 26 other neuromuscular disease controls. There was marked depletion of intramembranous particles in Duchenne dystrophy, whereas intramembranous particle density counts in other neuromuscular diseases were within normal limits. Therefore, the internal molecular architecture of the erythrocyte membrane is abnormal in Duchenne dystrophy, supporting the concept that a membrane defect involving multiple tissues is present in this disorder.
UR - http://www.scopus.com/inward/record.url?scp=0018394866&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0018394866&partnerID=8YFLogxK
M3 - Article
VL - 29
SP - 670
EP - 675
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 5
ER -