Free light chains in multiple sclerosis and infections of the CNS.

Charles DeCarli, M. A. Menegus, R. A. Rudick

Research output: Contribution to journalArticle

43 Scopus citations

Abstract

The intrathecal humoral immune response was analyzed in 83 patients with MS and 35 patients with acute CNS infections. CSF free kappa chains and CSF free lambda chains were quantified by radioimmunoassay; CSF IgG and albumin were measured by electroimmunodiffusion. The MS patients were characterized by higher levels of free kappa chains; free kappa:free lambda chain ratio; free kappa chain:albumin ratio; and IgG:albumin ratio. There were no differences in the level of free lambda chains or absolute concentration of IgG. A significant correlation was observed between free kappa chains and total IgG in MS and between free lambda chains and total IgG in infections, suggesting that the immune response was predominantly IgG-kappa in MS and IgG-lambda in infections.

Original languageEnglish (US)
Pages (from-to)1334-1338
Number of pages5
JournalNeurology
Volume37
Issue number8
StatePublished - Aug 1987
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)

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    DeCarli, C., Menegus, M. A., & Rudick, R. A. (1987). Free light chains in multiple sclerosis and infections of the CNS. Neurology, 37(8), 1334-1338.