Free erythrocyte porphyrin: hemoglobin ratios, serum ferritin, and transferrin saturation levels during treatment of infants with iron deficiency anemia

W. J. Thomas, H. M. Koenig, A. L. Lightsey, Ralph Green

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Free erythrocyte porphyrin:hemoglobin (FEP:Hb) ratios were determined on 20 infants with iron deficiency anemia. FEB:Hb ratios were compared with simultaneously drawn serum ferritin and serum transferrin saturation levels. FEP:Hb ratios dropped steadily during treatment of the anemic infants, but remained elevated compared to age matched nonanemic infants, until the anemia was corrected. FEP:Hb ratios detected iron deficiency when acute inflammatory disease was present. Serum ferritin levels and transferrin saturation failed to detect iron deficiency after iron therapy was started or when acute inflammatory disease was present. Measurement of FEP:Hb ratios is a reliable and practical way to make a prompt diagnosis of iron deficiency anemia in infants.

Original languageEnglish (US)
Pages (from-to)455-462
Number of pages8
JournalBlood
Volume49
Issue number3
StatePublished - 1977
Externally publishedYes

ASJC Scopus subject areas

  • Hematology

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