Frameshift suppressors. II. Genetic mapping and dominance studies

Donald L. Riddle, John R. Roth

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Suppressors specific for frameshift mutations have been studied. Six distinct suppressor loci have been identified on the genetic map of Salmonella typhimurium. These suppressor genes have been designated sufA through suf F. Suppressor mutations sufA, B, D and E are dominant, while sufF mutations are recessive to the wild-type allele. All dominant suppressor types are induced by the mutagen ICR-191. The recessive sufF mutations are induced by nitrosoguanidine. One dominant suppressor, sufD, coincides in map position to a glycyl-transfer RNA gene in Escherichia coli.

Original languageEnglish (US)
Pages (from-to)483-493
Number of pages11
JournalJournal of Molecular Biology
Volume66
Issue number3
DOIs
StatePublished - May 28 1972

ASJC Scopus subject areas

  • Virology

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