Suppressors specific for frameshift mutations have been studied. Six distinct suppressor loci have been identified on the genetic map of Salmonella typhimurium. These suppressor genes have been designated sufA through suf F. Suppressor mutations sufA, B, D and E are dominant, while sufF mutations are recessive to the wild-type allele. All dominant suppressor types are induced by the mutagen ICR-191. The recessive sufF mutations are induced by nitrosoguanidine. One dominant suppressor, sufD, coincides in map position to a glycyl-transfer RNA gene in Escherichia coli.
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