Abstract
Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 602-608 |
| Number of pages | 7 |
| Journal | Journals of Gerontology - Series A Biological Sciences and Medical Sciences |
| Volume | 69 A |
| Issue number | 5 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- Frailty
- Hip
- Older men.
- Osteoarthritis
ASJC Scopus subject areas
- Aging
- Geriatrics and Gerontology
- Medicine(all)
Cite this
Frailty and hip osteoarthritis in men in the MrOS cohort. / Wise, Barton L; Parimi, Neeta; Zhang, Yuqing; Cawthon, Peggy M.; Barrett-Connor, Elizabeth; Ensrud, Kristine E.; Lane, Nancy E.
In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 69 A, No. 5, 2014, p. 602-608.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Frailty and hip osteoarthritis in men in the MrOS cohort
AU - Wise, Barton L
AU - Parimi, Neeta
AU - Zhang, Yuqing
AU - Cawthon, Peggy M.
AU - Barrett-Connor, Elizabeth
AU - Ensrud, Kristine E.
AU - Lane, Nancy E
PY - 2014
Y1 - 2014
N2 - Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.
AB - Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.
KW - Frailty
KW - Hip
KW - Older men.
KW - Osteoarthritis
UR - http://www.scopus.com/inward/record.url?scp=84899128127&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899128127&partnerID=8YFLogxK
U2 - 10.1093/gerona/glt126
DO - 10.1093/gerona/glt126
M3 - Article
C2 - 24253535
AN - SCOPUS:84899128127
VL - 69 A
SP - 602
EP - 608
JO - The journals of gerontology. Series A, Biological sciences and medical sciences
JF - The journals of gerontology. Series A, Biological sciences and medical sciences
SN - 1079-5006
IS - 5
ER -