Frailty and hip osteoarthritis in men in the MrOS cohort

Barton L Wise, Neeta Parimi, Yuqing Zhang, Peggy M. Cawthon, Elizabeth Barrett-Connor, Kristine E. Ensrud, Nancy E Lane

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.

Original languageEnglish (US)
Pages (from-to)602-608
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume69 A
Issue number5
DOIs
StatePublished - 2014

Fingerprint

Hip Osteoarthritis
Hip Replacement Arthroplasties
Hip
Confidence Intervals
Osteoporotic Fractures
Arthritis
Weight Loss
Cross-Sectional Studies
Logistic Models
Odds Ratio
Morbidity
Mortality

Keywords

  • Frailty
  • Hip
  • Older men.
  • Osteoarthritis

ASJC Scopus subject areas

  • Aging
  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

Frailty and hip osteoarthritis in men in the MrOS cohort. / Wise, Barton L; Parimi, Neeta; Zhang, Yuqing; Cawthon, Peggy M.; Barrett-Connor, Elizabeth; Ensrud, Kristine E.; Lane, Nancy E.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 69 A, No. 5, 2014, p. 602-608.

Research output: Contribution to journalArticle

Wise, Barton L ; Parimi, Neeta ; Zhang, Yuqing ; Cawthon, Peggy M. ; Barrett-Connor, Elizabeth ; Ensrud, Kristine E. ; Lane, Nancy E. / Frailty and hip osteoarthritis in men in the MrOS cohort. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2014 ; Vol. 69 A, No. 5. pp. 602-608.
@article{4f8ba9fe70f2479b961f31aaa9f964d1,
title = "Frailty and hip osteoarthritis in men in the MrOS cohort",
abstract = "Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50{\%}, 42{\%}, and 8{\%}, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95{\%} confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95{\%} CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.",
keywords = "Frailty, Hip, Older men., Osteoarthritis",
author = "Wise, {Barton L} and Neeta Parimi and Yuqing Zhang and Cawthon, {Peggy M.} and Elizabeth Barrett-Connor and Ensrud, {Kristine E.} and Lane, {Nancy E}",
year = "2014",
doi = "10.1093/gerona/glt126",
language = "English (US)",
volume = "69 A",
pages = "602--608",
journal = "The journals of gerontology. Series A, Biological sciences and medical sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "5",

}

TY - JOUR

T1 - Frailty and hip osteoarthritis in men in the MrOS cohort

AU - Wise, Barton L

AU - Parimi, Neeta

AU - Zhang, Yuqing

AU - Cawthon, Peggy M.

AU - Barrett-Connor, Elizabeth

AU - Ensrud, Kristine E.

AU - Lane, Nancy E

PY - 2014

Y1 - 2014

N2 - Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.

AB - Background.Frailty has been associated in previous studies with increased mortality and morbidity, but little has been published on its association with arthritis. This study examined the association of hip osteoarthritis to frailty status in a longitudinal observational cohort of older men in the Osteoporotic Fractures in Men Study.Methods.Participants (N = 4,130) were men aged 65 years and older with complete frailty status and hip radiographs. We defined frailty as three or more of the following components: unintentional weight loss, weakness, self-reported exhaustion, low activity level, and slow walking speed. Men with intermediate stage status met one or two criteria while robust men had none. We defined radiographic hip osteoarthritis (RHOA) as a modified Croft score greater than or equal to 2 on hip radiograph. The relation of RHOA or total hip replacement (THR) to frailty status was examined in cross-sectional and incident analyses using logistic regression.Results.Prevalence of robust, intermediate, and frail status was 50%, 42%, and 8%, respectively. RHOA or THR was associated with increased odds of being frail or intermediate compared with robust (adjusted odds ratio = 1.45, 95% confidence interval [CI] 1.18, 1.78). Men with RHOA or THR were 1.27 times more likely to have incident frail or intermediate status compared with robust (95% CI: 1.19, 1.38).Conclusions.RHOA and THR are associated with greater frailty status in older men, suggesting that interventions to reduce frailty should be evaluated in older men with either RHOA or THR.

KW - Frailty

KW - Hip

KW - Older men.

KW - Osteoarthritis

UR - http://www.scopus.com/inward/record.url?scp=84899128127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899128127&partnerID=8YFLogxK

U2 - 10.1093/gerona/glt126

DO - 10.1093/gerona/glt126

M3 - Article

C2 - 24253535

AN - SCOPUS:84899128127

VL - 69 A

SP - 602

EP - 608

JO - The journals of gerontology. Series A, Biological sciences and medical sciences

JF - The journals of gerontology. Series A, Biological sciences and medical sciences

SN - 1079-5006

IS - 5

ER -