Fragile X syndrome with anxiety disorder and exceptional verbal intelligence

Kathleen Angkustsiri, Juthamas Wirojanan, Lesley J. Deprey, Louise W. Gane, Randi J Hagerman

Research output: Contribution to journalArticlepeer-review

12 Scopus citations


Fragile X syndrome (FXS) is often characterized by mental retardation. However, FXS is also associated with significant emotional and psychiatric problems, including anxiety, depression, attention difficulties, and learning disabilities in the presence of a normal IQ. This report describes a unique woman with the full mutation of FXS who has an exceptional profile of above-average intelligence combined with significant impairments due to anxiety and learning disability. Women with FXS can present primarily with learning and emotional problems, and clinicians should consider FXS in these women regardless of their IQ.

Original languageEnglish (US)
Pages (from-to)376-379
Number of pages4
JournalAmerican Journal of Medical Genetics, Part A
Issue number3
StatePublished - Feb 1 2008


  • Anxiety disorder
  • Fragile X syndrome
  • Verbal intelligence

ASJC Scopus subject areas

  • Genetics(clinical)


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