Fragile X syndrome: Psychiatric manifestations, assessment and emerging therapies

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Abstract

Fragile X Syndrome (FXS), the most common inherited cause of intellectual disabilities, is an X-linked dominant disorder caused by the amplification of a CGG repeat in the 5' untranslated region of the fragile X mental retardation gene 1 (FMR1). Prevalence estimates of the disorder are approximately 1/3600. Psychiatric manifestations of the disorder include anxiety, attention deficit hyperactivity disorder, autism, mood instability and aggression. In this article we review the above psychiatric manifestations and challenges to accurate assessment. We also discuss how the neurobiological underpinnings of these symptoms are beginning to be understood and can help guide treatment.

Original languageEnglish (US)
Pages (from-to)53-58
Number of pages6
JournalCurrent Psychiatry Reviews
Volume9
Issue number1
DOIs
StatePublished - 2013

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Keywords

  • Assessment
  • Fragile x syndrome
  • Neurobiology
  • Psychiatric symptoms
  • Treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health

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