Fragile X syndrome: New developments

Susan W. Harris, Randi J Hagerman

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Molecular and clinical studies have demonstrated a spectrum of involvement in fragile X syndrome, such that some individuals may have only emotional problems and others may have more significant cognitive involvement. The new fragile X mental retardation 1 protein studies have been helpful in assessing milder forms of involvement and have detected some individuals with the premutation who are significantly affected. The fragile X mental retardation 1 protein appears to be a translation regulator and one of the first proteins produced in the neuron with metabotropic glutamate receptor stimulation. It is hypothesized that fragile X mental retardation 1 protein is necessary for the process of pruning and maturation of selected synapses, perhaps through the regulation of translation of other messages.

Original languageEnglish (US)
Pages (from-to)573-578
Number of pages6
JournalCurrent Opinion in Psychiatry
Volume12
Issue number5
DOIs
StatePublished - 1999
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health

Fingerprint Dive into the research topics of 'Fragile X syndrome: New developments'. Together they form a unique fingerprint.

  • Cite this