Abstract
Although fragile X syndrome is typically considered a pediatric developmental disorder, many manifestations persist or develop in adulthood. Manifestations depend on the length of the CGG repeat at the front end of the FMR1 gene. Patients with the premutation (55 to 200 repeats) have typically normal cognitive abilities. With increasing age, however, consequences of RNA toxicity, including primary ovarian insufficiency, the fragile X-associated tremor ataxia syndrome, fibromyalgia, hypothyroidism, neuropathy, and psychiatric problems including anxiety and depression, may develop. Patients with the full mutation (greater than 200 CGG repeats) have significant cognitive impairment ranging from learning disabilities, particularly in girls, to severe intellectual disability and autism in males. Medical problems are usually related to connective-tissue abnormalities, seizures, or psychiatric problems, including mood instability, anxiety, and/or aggression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 32-49 |
| Number of pages | 18 |
| Journal | CONTINUUM Lifelong Learning in Neurology |
| Volume | 15 |
| Issue number | 6 |
| DOIs | |
| State | Published - Dec 2009 |
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Keywords
- The premutation produces excess mRNA leading to an RNA toxicity causing fragile X-associated tremor ataxia syndrome (FXTAS) and primary ovarian insufficiency
- Whereas the full mutation produces little or no mRNA and a lack of FMRP
- Which leads to fragile X syndrome (FXS). The molecular mechanisms of involvement are therefore different between the premutation and the full mutation
ASJC Scopus subject areas
- Clinical Neurology
- Genetics(clinical)
Cite this
Fragile X syndrome and associated disorders in adulthood. / Hagerman, Randi J.
In: CONTINUUM Lifelong Learning in Neurology, Vol. 15, No. 6, 12.2009, p. 32-49.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fragile X syndrome and associated disorders in adulthood
AU - Hagerman, Randi J
PY - 2009/12
Y1 - 2009/12
N2 - Although fragile X syndrome is typically considered a pediatric developmental disorder, many manifestations persist or develop in adulthood. Manifestations depend on the length of the CGG repeat at the front end of the FMR1 gene. Patients with the premutation (55 to 200 repeats) have typically normal cognitive abilities. With increasing age, however, consequences of RNA toxicity, including primary ovarian insufficiency, the fragile X-associated tremor ataxia syndrome, fibromyalgia, hypothyroidism, neuropathy, and psychiatric problems including anxiety and depression, may develop. Patients with the full mutation (greater than 200 CGG repeats) have significant cognitive impairment ranging from learning disabilities, particularly in girls, to severe intellectual disability and autism in males. Medical problems are usually related to connective-tissue abnormalities, seizures, or psychiatric problems, including mood instability, anxiety, and/or aggression.
AB - Although fragile X syndrome is typically considered a pediatric developmental disorder, many manifestations persist or develop in adulthood. Manifestations depend on the length of the CGG repeat at the front end of the FMR1 gene. Patients with the premutation (55 to 200 repeats) have typically normal cognitive abilities. With increasing age, however, consequences of RNA toxicity, including primary ovarian insufficiency, the fragile X-associated tremor ataxia syndrome, fibromyalgia, hypothyroidism, neuropathy, and psychiatric problems including anxiety and depression, may develop. Patients with the full mutation (greater than 200 CGG repeats) have significant cognitive impairment ranging from learning disabilities, particularly in girls, to severe intellectual disability and autism in males. Medical problems are usually related to connective-tissue abnormalities, seizures, or psychiatric problems, including mood instability, anxiety, and/or aggression.
KW - The premutation produces excess mRNA leading to an RNA toxicity causing fragile X-associated tremor ataxia syndrome (FXTAS) and primary ovarian insufficiency
KW - Whereas the full mutation produces little or no mRNA and a lack of FMRP
KW - Which leads to fragile X syndrome (FXS). The molecular mechanisms of involvement are therefore different between the premutation and the full mutation
UR - http://www.scopus.com/inward/record.url?scp=78650748395&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78650748395&partnerID=8YFLogxK
U2 - 10.1212/01.CON.0000348876.24317.0e
DO - 10.1212/01.CON.0000348876.24317.0e
M3 - Article
AN - SCOPUS:78650748395
VL - 15
SP - 32
EP - 49
JO - CONTINUUM Lifelong Learning in Neurology
JF - CONTINUUM Lifelong Learning in Neurology
SN - 1080-2371
IS - 6
ER -