Fragile X syndrome: an overview of cause, characteristics, assessment and management

Hayley Crawford, Leonard Abbeduto, Scott S. Hall, Rebecca Hardiman, David Hessl, Jane E. Roberts, Gaia Scerif, Andrew C. Stanfield, Jeremy Turk, Chris Oliver

Research output: Contribution to journalReview articlepeer-review


Fragile X syndrome (FXS) is the most common identifiable cause of inherited intellectual disability and autism spectrum conditions, and is associated with a range of physical, cognitive and behavioural characteristics. Alongside intellectual disability, heightened rates of autism spectrum disorder, anxiety disorders, attention-deficit-hyperactivity disorder, self-injury and aggression are reported. Timely identification of FXS as well as assessments of common co-morbid psychological conditions and underlying health problems are essential to ensure individuals with FXS receive appropriate support. This article provides an overview for clinicians of current literature on the cause of FXS as well as the key physical, cognitive, and behavioural characteristics with a focus on children and adolescents.

Original languageEnglish (US)
Pages (from-to)400-403
Number of pages4
JournalPaediatrics and Child Health (United Kingdom)
Issue number11
StatePublished - Nov 2020
Externally publishedYes


  • anxiety
  • attention-deficit-hyperactivity-disorder
  • autism spectrum disorder
  • fragile X syndrome
  • intellectual disability

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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