Abstract
Fragile X syndrome (FXS) is the most common inherited cause of mental retardation known and has a strong association with autism. Approximately 2-6 percent of males with autism have FXS, and 15-33 percent of children with FXS have autism (Bailey et al., 2001b; Rogers et al., 2001; Hagerman, 2002). FXS represents a distinct subgroup of autism, and the study of the behavioral phenotype, neurobiology, and molecular genetics of FXS could lead to new insights regarding pathophysiology that may be applicable to other causes of autism. FXS is a model of how a single-gene disorder can affect the expression of multiple genes that may be held in common with other etiologies of autism.
| Original language | English (US) |
|---|---|
| Title of host publication | The Neurobiology of Autism |
| Publisher | The Johns Hopkins University Press |
| Pages | 251-264 |
| Number of pages | 14 |
| ISBN (Print) | 9780801880476 |
| State | Published - 2005 |
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ASJC Scopus subject areas
- Social Sciences(all)
Cite this
Fragile X syndrome. / Hagerman, Randi J.
The Neurobiology of Autism. The Johns Hopkins University Press, 2005. p. 251-264.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Fragile X syndrome
AU - Hagerman, Randi J
PY - 2005
Y1 - 2005
N2 - Fragile X syndrome (FXS) is the most common inherited cause of mental retardation known and has a strong association with autism. Approximately 2-6 percent of males with autism have FXS, and 15-33 percent of children with FXS have autism (Bailey et al., 2001b; Rogers et al., 2001; Hagerman, 2002). FXS represents a distinct subgroup of autism, and the study of the behavioral phenotype, neurobiology, and molecular genetics of FXS could lead to new insights regarding pathophysiology that may be applicable to other causes of autism. FXS is a model of how a single-gene disorder can affect the expression of multiple genes that may be held in common with other etiologies of autism.
AB - Fragile X syndrome (FXS) is the most common inherited cause of mental retardation known and has a strong association with autism. Approximately 2-6 percent of males with autism have FXS, and 15-33 percent of children with FXS have autism (Bailey et al., 2001b; Rogers et al., 2001; Hagerman, 2002). FXS represents a distinct subgroup of autism, and the study of the behavioral phenotype, neurobiology, and molecular genetics of FXS could lead to new insights regarding pathophysiology that may be applicable to other causes of autism. FXS is a model of how a single-gene disorder can affect the expression of multiple genes that may be held in common with other etiologies of autism.
UR - http://www.scopus.com/inward/record.url?scp=84898084976&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84898084976&partnerID=8YFLogxK
M3 - Chapter
SN - 9780801880476
SP - 251
EP - 264
BT - The Neurobiology of Autism
PB - The Johns Hopkins University Press
ER -