Abstract
Fragile X syndrome (FXS) is the most common inherited cause of mental retardation known and has a strong association with autism. Approximately 2-6 percent of males with autism have FXS, and 15-33 percent of children with FXS have autism (Bailey et al., 2001b; Rogers et al., 2001; Hagerman, 2002). FXS represents a distinct subgroup of autism, and the study of the behavioral phenotype, neurobiology, and molecular genetics of FXS could lead to new insights regarding pathophysiology that may be applicable to other causes of autism. FXS is a model of how a single-gene disorder can affect the expression of multiple genes that may be held in common with other etiologies of autism.
| Original language | English (US) |
|---|---|
| Title of host publication | The Neurobiology of Autism |
| Publisher | The Johns Hopkins University Press |
| Pages | 251-264 |
| Number of pages | 14 |
| ISBN (Print) | 9780801880476 |
| Publication status | Published - 2005 |
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ASJC Scopus subject areas
- Social Sciences(all)
Cite this
Hagerman, R. J. (2005). Fragile X syndrome. In The Neurobiology of Autism (pp. 251-264). The Johns Hopkins University Press.