Fragile X checklists: A meta-analysis and development of a simplified universal clinical checklist

Toni Kasole Lubala, Aimé Lumaka, Gray Kanteng, Léon Mutesa, Olivier Mukuku, Stanislas Wembonyama, Randi J Hagerman, Oscar Numbi Luboya, Prosper Lukusa Tshilobo

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Background: Clinical checklists available have been developed to assess the risk of a positive Fragile X syndrome but they include relatively small sample sizes. Therefore, we carried out a meta-analysis that included statistical pooling of study results to obtain accurate figures on the prevalence of clinical predictors of Fragile X syndrome among patients with intellectual disability, thereby helping health professionals to improve their referrals for Fragile X testing. Methods: All published studies consisting of cytogenetic and/or molecular screening for fragile X syndrome among patients with intellectual disability, were eligible for the meta-analysis. All patients enrolled in clinical checklists trials of Fragile X syndrome were eligible for this review, with no exclusion based on ethnicity or age. Odds ratio values, with 95% confidence intervals as well as Cronbach coefficient alpha, was reported to assess the frequency of clinical characteristics in subjects with intellectual disability with and without the fragile X mutation to determine the most discriminating. Results: The following features were strongly associated with Fragile X syndrome: skin soft and velvety on the palms with redundancy of skin on the dorsum of hand [OR: 16.85 (95% CI 10.4-27.3; α:0.97)], large testes [OR: 7.14 (95% CI 5.53-9.22; α: 0.80)], large and prominent ears [OR: 18.62 (95% CI 14.38-24.1; α: 0.98)], pale blue eyes [OR: 8.97 (95% CI 4.75-16.97; α: 0.83)], family history of intellectual disability [OR: 3.43 (95% CI 2.76-4.27; α: 0.81)] as well as autistic-like behavior [OR: 3.08 (95% CI 2.48-3.83; α: 0.77)], Flat feet [OR: 11.53 (95% CI 6.79-19.56; α:0.91)], plantar crease [OR: 3.74 (95% CI 2.67-5.24; α: 0.70)]. We noted a weaker positive association between transverse palmar crease [OR: 2.68 (95% CI 1.70-4.18; α: 0.51)], elongated face [OR: 3.69 (95% CI 2.84-4.81; α: 0.63)]; hyperextensible metacarpo-phalangeal joints [OR: 2.68 (95% CI 2.15-3.34; α: 0.57)] and the Fragile X syndrome. Conclusion: This study has identified the highest risk features for patients with Fragile X syndrome that have been used to design a universal clinical checklist.

Original languageEnglish (US)
JournalMolecular Genetics and Genomic Medicine
DOIs
StateAccepted/In press - Jan 1 2018

Keywords

  • Checklists
  • Clinical features
  • Fragile X
  • Meta-analysis

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)
  • Molecular Biology

Fingerprint Dive into the research topics of 'Fragile X checklists: A meta-analysis and development of a simplified universal clinical checklist'. Together they form a unique fingerprint.

  • Cite this

    Lubala, T. K., Lumaka, A., Kanteng, G., Mutesa, L., Mukuku, O., Wembonyama, S., Hagerman, R. J., Luboya, O. N., & Lukusa Tshilobo, P. (Accepted/In press). Fragile X checklists: A meta-analysis and development of a simplified universal clinical checklist. Molecular Genetics and Genomic Medicine. https://doi.org/10.1002/mgg3.398