Fractionated radioimmunotherapy of B-cell malignancies with131I-lym-1

Gerald L Denardo, Sally J. DeNardo, Lois F. O'Grady, Norman B. Levy, Gregory P. Adams, Stanley L. Mills

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135 Scopus citations

Abstract

Eighteen patients with Stage 4 B-cell malignancies, which were primarily of intermediate or high grade and progressive despite multiple drug chemotherapy and external irradiation, were treated with fractionated doses of 131I-labeled Lym-1. Lym-1 is an IgG2a monoclonal antibody that was produced by immunizing mice with Raji cell nuclei that originated from a patient with African Burkitt's lymphoma. Despite advanced disease, 10 of the patients had objective evidence for a complete or partial remission. Toxicity was very modest except in one patient who developed hypotension. Dose-dependent hepatic uptake of Lym-1 was observed in the patients and in BALB/c mice suggesting receptor-mediated recognition of this murine antibody.

Original languageEnglish (US)
JournalCancer Research
Volume50
Issue number3 SUPPL.
StatePublished - 1990

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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    Denardo, G. L., DeNardo, S. J., O'Grady, L. F., Levy, N. B., Adams, G. P., & Mills, S. L. (1990). Fractionated radioimmunotherapy of B-cell malignancies with131I-lym-1. Cancer Research, 50(3 SUPPL.).