Abstract
PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 775-783 |
| Number of pages | 9 |
| Journal | Eye |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2011 |
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Keywords
- epiretinal membrane
- Fourier-domain optical coherence tomography
- macular morphology
- microperimetry
- Stratus OCT
ASJC Scopus subject areas
- Ophthalmology
Cite this
Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane : Correlation between macular morphology and visual function. / Pilli, S.; Lim, P.; Zawadzki, Robert; Choi, S. S.; Werner, John S; Park, Susanna Soon Chun.
In: Eye, Vol. 25, No. 6, 06.2011, p. 775-783.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane
T2 - Correlation between macular morphology and visual function
AU - Pilli, S.
AU - Lim, P.
AU - Zawadzki, Robert
AU - Choi, S. S.
AU - Werner, John S
AU - Park, Susanna Soon Chun
PY - 2011/6
Y1 - 2011/6
N2 - PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.
AB - PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.
KW - epiretinal membrane
KW - Fourier-domain optical coherence tomography
KW - macular morphology
KW - microperimetry
KW - Stratus OCT
UR - http://www.scopus.com/inward/record.url?scp=79958749887&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=79958749887&partnerID=8YFLogxK
U2 - 10.1038/eye.2011.55
DO - 10.1038/eye.2011.55
M3 - Article
C2 - 21436847
AN - SCOPUS:79958749887
VL - 25
SP - 775
EP - 783
JO - Eye (Basingstoke)
JF - Eye (Basingstoke)
SN - 0950-222X
IS - 6
ER -