Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane: Correlation between macular morphology and visual function

S. Pilli, P. Lim, Robert Zawadzki, S. S. Choi, John S Werner, Susanna Soon Chun Park

Research output: Contribution to journalArticle

33 Scopus citations


PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
Issue number6
StatePublished - Jun 2011



  • epiretinal membrane
  • Fourier-domain optical coherence tomography
  • macular morphology
  • microperimetry
  • Stratus OCT

ASJC Scopus subject areas

  • Ophthalmology

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