Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane: Correlation between macular morphology and visual function

S. Pilli, P. Lim, Robert Zawadzki, S. S. Choi, John S Werner, Susanna Soon Chun Park

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.

Original languageEnglish (US)
Pages (from-to)775-783
Number of pages9
JournalEye
Volume25
Issue number6
DOIs
StatePublished - Jun 2011

Fingerprint

Epiretinal Membrane
Optical Coherence Tomography
Visual Acuity
Membranes

Keywords

  • epiretinal membrane
  • Fourier-domain optical coherence tomography
  • macular morphology
  • microperimetry
  • Stratus OCT

ASJC Scopus subject areas

  • Ophthalmology

Cite this

@article{a9d6a2ee18ac42c5889d3673d8dae64a,
title = "Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane: Correlation between macular morphology and visual function",
abstract = "PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85{\%}) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25{\%} of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.",
keywords = "epiretinal membrane, Fourier-domain optical coherence tomography, macular morphology, microperimetry, Stratus OCT",
author = "S. Pilli and P. Lim and Robert Zawadzki and Choi, {S. S.} and Werner, {John S} and Park, {Susanna Soon Chun}",
year = "2011",
month = "6",
doi = "10.1038/eye.2011.55",
language = "English (US)",
volume = "25",
pages = "775--783",
journal = "Eye (Basingstoke)",
issn = "0950-222X",
publisher = "Nature Publishing Group",
number = "6",

}

TY - JOUR

T1 - Fourier-domain optical coherence tomography of eyes with idiopathic epiretinal membrane

T2 - Correlation between macular morphology and visual function

AU - Pilli, S.

AU - Lim, P.

AU - Zawadzki, Robert

AU - Choi, S. S.

AU - Werner, John S

AU - Park, Susanna Soon Chun

PY - 2011/6

Y1 - 2011/6

N2 - PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.

AB - PurposeThe purpose of this study is to evaluate the macular morphological changes associated with idiopathic epiretinal membrane (iERM) using high-resolution Fourier-domain optical coherence tomography (FD-OCT), as they correlate with visual acuity and microperimetry (MP-1).MethodsIn all, 24 eyes (19 subjects) with iERM were imaged prospectively using FD-OCT with axial resolution of 4.5 m and transverse resolution of 10 to 15 m. MP-1 and Stratus OCT were carried out in a subset of eyes.ResultsThe mean log of the minimum angle of resolution best-corrected visual acuity (BCVA) was 0.180.16 (range: 0.08 to 0.48, Snellen equivalent 20/15 1 to 20/60). ERM was visualized in all 24 eyes with FD-OCT and in 17 eyes (85%) of 20 eyes imaged with Stratus OCT. Although BCVA correlated with macular thickening in the central 1 mm sub-field of the Stratus ETDRS (P0.0005) and macular volume (central 3 mm area) on FD-OCT (P < 0.0001), macular thickening on thickness map and volume correlated poorly with decrease in macular sensitivity on MP-1 (P < 0.16). On FD-OCT, foveal morphological changes correlated best with decrease in BCVA, the strongest being central foveal thickness (P0.0001). Other significant changes included blurring of the foveal inner segment-outer segment (IS-OS) junction and/or Verhoeff's membrane, vitreal displacement of foveal outer nuclear layer and foveal detachment (P0.05). Foveal IS-OS junction disruption was seen in 25% of eyes on Stratus OCT but in none of the eyes on FD-OCT.ConclusionFD-OCT allowed improved visualization of ERM and associated foveal morphological changes that correlated best with BCVA. Macular thickening correlated weakly with decreased macular function as assessed by MP-1.

KW - epiretinal membrane

KW - Fourier-domain optical coherence tomography

KW - macular morphology

KW - microperimetry

KW - Stratus OCT

UR - http://www.scopus.com/inward/record.url?scp=79958749887&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79958749887&partnerID=8YFLogxK

U2 - 10.1038/eye.2011.55

DO - 10.1038/eye.2011.55

M3 - Article

C2 - 21436847

AN - SCOPUS:79958749887

VL - 25

SP - 775

EP - 783

JO - Eye (Basingstoke)

JF - Eye (Basingstoke)

SN - 0950-222X

IS - 6

ER -