Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen

Stacey S. Choi, Robert Zawadzki, Mark A. Greiner, John S Werner, John L Keltner

Research output: Contribution to journalArticle

36 Scopus citations

Abstract

Background:: New technology allows more precise definition of structural alterations of all retinal layers although it has not been used previously in cases of optic disc drusen. METHODS:: Using Stratus and Fourier domain (FD) optical coherence tomography (OCT) and adaptive optics (AO) through a flood-illuminated fundus camera, we studied the retinas of a patient with long-standing optic disc drusen and acute visual loss at high altitude attributed to ischemic optic neuropathy. RESULTS:: Stratus OCT and FD-OCT confirmed severe thinning of the retinal nerve fiber layer (RNFL). FD-OCT revealed disturbances in the photoreceptor layer heretofore not described in optic disc drusen patients. AO confirmed the FD-OCT findings in the photoreceptor layer and also showed reduced cone density at retinal locations associated with reduced visual sensitivity. CONCLUSIONS:: Based on this study, changes occur not only in the RNFL but also in the photoreceptor layer in optic nerve drusen complicated by ischemic optic neuropathy. This is the first reported application of FD-OCT and the AO to this condition. Such new imaging technology may in the future allow monitoring of disease progression more precisely and accurately.

Original languageEnglish (US)
Pages (from-to)120-125
Number of pages6
JournalJournal of Neuro-Ophthalmology
Volume28
Issue number2
DOIs
StatePublished - Jun 2008

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology
  • Medicine(all)

Fingerprint Dive into the research topics of 'Fourier-domain optical coherence tomography and adaptive optics reveal nerve fiber layer loss and photoreceptor changes in a patient with optic nerve drusen'. Together they form a unique fingerprint.

  • Cite this