Four-Dimensional Magnetic Resonance Velocity Mapping of Blood Flow Patterns in the Aorta in Patients with Atherosclerotic Coronary Artery Disease Compared to Age-Matched Normal Subjects

Hugo G. Bogren, Michael H. Buonocore, Richard J. Valente

Research output: Contribution to journalArticle

65 Citations (Scopus)

Abstract

Purpose: To test the hypothesis that age and atherosclerotic coronary artery disease (CAD) may influence aortic blood flow patterns. Materials and Methods: A total of 21 patients with CAD, 37-86 years old, were studied, together with 20 age-matched normal subjects. Time-resolved, three-direction velocity data over an entire volume were obtained with sequential single-slice two-dimensional cardiac-gated magnetic resonance (MR) velocity-encoded phase-contrast sequences. Results: In both normal subjects and CAD patients, the time it took for particles to travel from aortic valve to descending aorta was significantly longer in the elderly age group than in the younger (37-46 years old). This time was significantly longer in patients than in normal subjects. Systolic velocities were significantly higher in young normal subjects than in elderly normal subjects, and significantly lower in CAD patients than in age-matched normal subjects. Retrograde velocity was higher in CAD patients than in normal subjects, and higher in elderly CAD patients than in young. Conclusion: CAD patients have abnormal blood flow patterns in the aorta compared with age-matched normal subjects, especially young patients ages 37-46. The aging process has a similar effect on blood flow patterns as atherosclerosis. Ascending aorta flow is chaotic in some very elderly normal subjects and in CAD patients of all ages. Chaotic aortic flow may result in reduced blood flow into the coronary arteries.

Original languageEnglish (US)
Pages (from-to)417-427
Number of pages11
JournalJournal of Magnetic Resonance Imaging
Volume19
Issue number4
DOIs
StatePublished - Apr 2004

Fingerprint

Blood Flow Velocity
Aorta
Coronary Artery Disease
Magnetic Resonance Spectroscopy
Thoracic Aorta
Aortic Valve
Atherosclerosis
Coronary Vessels
Age Groups

Keywords

  • Aortic flow in CAD
  • Blood flow patterns
  • Chaotic flow
  • Four-dimensional magnetic resonance velocity mapping
  • Retrograde flow

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Four-Dimensional Magnetic Resonance Velocity Mapping of Blood Flow Patterns in the Aorta in Patients with Atherosclerotic Coronary Artery Disease Compared to Age-Matched Normal Subjects. / Bogren, Hugo G.; Buonocore, Michael H.; Valente, Richard J.

In: Journal of Magnetic Resonance Imaging, Vol. 19, No. 4, 04.2004, p. 417-427.

Research output: Contribution to journalArticle

@article{83ae8e953460495280a26e91449b9d07,
title = "Four-Dimensional Magnetic Resonance Velocity Mapping of Blood Flow Patterns in the Aorta in Patients with Atherosclerotic Coronary Artery Disease Compared to Age-Matched Normal Subjects",
abstract = "Purpose: To test the hypothesis that age and atherosclerotic coronary artery disease (CAD) may influence aortic blood flow patterns. Materials and Methods: A total of 21 patients with CAD, 37-86 years old, were studied, together with 20 age-matched normal subjects. Time-resolved, three-direction velocity data over an entire volume were obtained with sequential single-slice two-dimensional cardiac-gated magnetic resonance (MR) velocity-encoded phase-contrast sequences. Results: In both normal subjects and CAD patients, the time it took for particles to travel from aortic valve to descending aorta was significantly longer in the elderly age group than in the younger (37-46 years old). This time was significantly longer in patients than in normal subjects. Systolic velocities were significantly higher in young normal subjects than in elderly normal subjects, and significantly lower in CAD patients than in age-matched normal subjects. Retrograde velocity was higher in CAD patients than in normal subjects, and higher in elderly CAD patients than in young. Conclusion: CAD patients have abnormal blood flow patterns in the aorta compared with age-matched normal subjects, especially young patients ages 37-46. The aging process has a similar effect on blood flow patterns as atherosclerosis. Ascending aorta flow is chaotic in some very elderly normal subjects and in CAD patients of all ages. Chaotic aortic flow may result in reduced blood flow into the coronary arteries.",
keywords = "Aortic flow in CAD, Blood flow patterns, Chaotic flow, Four-dimensional magnetic resonance velocity mapping, Retrograde flow",
author = "Bogren, {Hugo G.} and Buonocore, {Michael H.} and Valente, {Richard J.}",
year = "2004",
month = "4",
doi = "10.1002/jmri.20018",
language = "English (US)",
volume = "19",
pages = "417--427",
journal = "Journal of Magnetic Resonance Imaging",
issn = "1053-1807",
publisher = "John Wiley and Sons Inc.",
number = "4",

}

TY - JOUR

T1 - Four-Dimensional Magnetic Resonance Velocity Mapping of Blood Flow Patterns in the Aorta in Patients with Atherosclerotic Coronary Artery Disease Compared to Age-Matched Normal Subjects

AU - Bogren, Hugo G.

AU - Buonocore, Michael H.

AU - Valente, Richard J.

PY - 2004/4

Y1 - 2004/4

N2 - Purpose: To test the hypothesis that age and atherosclerotic coronary artery disease (CAD) may influence aortic blood flow patterns. Materials and Methods: A total of 21 patients with CAD, 37-86 years old, were studied, together with 20 age-matched normal subjects. Time-resolved, three-direction velocity data over an entire volume were obtained with sequential single-slice two-dimensional cardiac-gated magnetic resonance (MR) velocity-encoded phase-contrast sequences. Results: In both normal subjects and CAD patients, the time it took for particles to travel from aortic valve to descending aorta was significantly longer in the elderly age group than in the younger (37-46 years old). This time was significantly longer in patients than in normal subjects. Systolic velocities were significantly higher in young normal subjects than in elderly normal subjects, and significantly lower in CAD patients than in age-matched normal subjects. Retrograde velocity was higher in CAD patients than in normal subjects, and higher in elderly CAD patients than in young. Conclusion: CAD patients have abnormal blood flow patterns in the aorta compared with age-matched normal subjects, especially young patients ages 37-46. The aging process has a similar effect on blood flow patterns as atherosclerosis. Ascending aorta flow is chaotic in some very elderly normal subjects and in CAD patients of all ages. Chaotic aortic flow may result in reduced blood flow into the coronary arteries.

AB - Purpose: To test the hypothesis that age and atherosclerotic coronary artery disease (CAD) may influence aortic blood flow patterns. Materials and Methods: A total of 21 patients with CAD, 37-86 years old, were studied, together with 20 age-matched normal subjects. Time-resolved, three-direction velocity data over an entire volume were obtained with sequential single-slice two-dimensional cardiac-gated magnetic resonance (MR) velocity-encoded phase-contrast sequences. Results: In both normal subjects and CAD patients, the time it took for particles to travel from aortic valve to descending aorta was significantly longer in the elderly age group than in the younger (37-46 years old). This time was significantly longer in patients than in normal subjects. Systolic velocities were significantly higher in young normal subjects than in elderly normal subjects, and significantly lower in CAD patients than in age-matched normal subjects. Retrograde velocity was higher in CAD patients than in normal subjects, and higher in elderly CAD patients than in young. Conclusion: CAD patients have abnormal blood flow patterns in the aorta compared with age-matched normal subjects, especially young patients ages 37-46. The aging process has a similar effect on blood flow patterns as atherosclerosis. Ascending aorta flow is chaotic in some very elderly normal subjects and in CAD patients of all ages. Chaotic aortic flow may result in reduced blood flow into the coronary arteries.

KW - Aortic flow in CAD

KW - Blood flow patterns

KW - Chaotic flow

KW - Four-dimensional magnetic resonance velocity mapping

KW - Retrograde flow

UR - http://www.scopus.com/inward/record.url?scp=1842537978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1842537978&partnerID=8YFLogxK

U2 - 10.1002/jmri.20018

DO - 10.1002/jmri.20018

M3 - Article

C2 - 15065165

AN - SCOPUS:1842537978

VL - 19

SP - 417

EP - 427

JO - Journal of Magnetic Resonance Imaging

JF - Journal of Magnetic Resonance Imaging

SN - 1053-1807

IS - 4

ER -