Abstract
Nutrients in the intestine inhibit food intake via an action on the vagal afferent pathway. The aim of the present study was to use immunochemical detection of Fos protein-like immunoreactivity (FLI) in the brainstem to trace the neuronal pathways activated by intestinal nutrients. Perfusion of the intestine of awake rats via an indwelling duodenal catheter with iso-osmotic mannitol, hydrochloric acid or casein hydrolysate had no effect on the number of FLI neurons in the nucleus of the solitary tract (NTS). Lipid emulsion (20%) and 2.7 M glucose significantly increased the number of immunopositive cells in the NTS. There was a significant increase in the number of immunopositive cells from caudal to rostral NTS. Nutrients effective at decreasing food intake (carbohydrate and fat) produced significant increases in Fos-like immunopositive cells in the NTS.
Original language | English (US) |
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Pages (from-to) | 266-270 |
Number of pages | 5 |
Journal | Brain Research |
Volume | 663 |
Issue number | 2 |
DOIs | |
State | Published - Nov 14 1994 |
Keywords
- Carbohydrate
- Fos-like immunoreactivity
- Immunocytochemistry
- Lipid
- Nucleus of the solitary tract
- Small intestine
ASJC Scopus subject areas
- Developmental Biology
- Molecular Biology
- Clinical Neurology
- Neuroscience(all)