Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires

Shih Chieh J Huang, Alexander B. Artyukhin, Julio A. Martinez, Donald J. Sirbuly, Yinmin Wang, Jiann Wen Ju, Pieter Stroeve, Aleksandr Noy

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Curved lipid membranes are ubiquitous in living systems and play an important role in many biological processes. To understand how curvature and lipid composition affect membrane formation and fluidity, we have assembled and studied mixed 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) supported lipid bilayers on amorphous silicon nanowires grown around carbon nanotube cores with controlled wire diameters ranging from 20 to 200 nm. We found that lipid vesicles fused onto nanowire substrates and formed continuous bilayers for all DOPC-DOPE mixtures tested (with the DOPE content of up to 30%). Our measurements demonstrate that nanowire-supported bilayers are mobile, exhibit fast recovery after photobleaching, and have a low concentration of defects. Lipid diffusion coefficients in these high-curvature tubular membranes are comparable to the values reported for flat supported bilayers and increase slightly with decreasing nanowire diameter. A free space diffusion model adequately describes the effect of bilayer curvature on the lipid mobility for nanowire substrates with diameters greater than 50 nm, but shows significant deviations from the experimental values for smaller diameter nanowires.

Original languageEnglish (US)
Pages (from-to)3355-3359
Number of pages5
JournalNano Letters
Volume7
Issue number11
DOIs
StatePublished - Nov 2007
Externally publishedYes

Fingerprint

Lipid bilayers
Polysilicon
Nanowires
lipids
nanowires
Lipids
curvature
membranes
Membranes
Cable cores
Photobleaching
Carbon Nanotubes
Fluidity
Substrates
Membrane Lipids
Amorphous silicon
amorphous silicon
low concentrations
Carbon nanotubes
diffusion coefficient

ASJC Scopus subject areas

  • Materials Science(all)
  • Electronic, Optical and Magnetic Materials
  • Chemistry (miscellaneous)

Cite this

Huang, S. C. J., Artyukhin, A. B., Martinez, J. A., Sirbuly, D. J., Wang, Y., Ju, J. W., ... Noy, A. (2007). Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires. Nano Letters, 7(11), 3355-3359. https://doi.org/10.1021/nl071641w

Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires. / Huang, Shih Chieh J; Artyukhin, Alexander B.; Martinez, Julio A.; Sirbuly, Donald J.; Wang, Yinmin; Ju, Jiann Wen; Stroeve, Pieter; Noy, Aleksandr.

In: Nano Letters, Vol. 7, No. 11, 11.2007, p. 3355-3359.

Research output: Contribution to journalArticle

Huang, SCJ, Artyukhin, AB, Martinez, JA, Sirbuly, DJ, Wang, Y, Ju, JW, Stroeve, P & Noy, A 2007, 'Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires', Nano Letters, vol. 7, no. 11, pp. 3355-3359. https://doi.org/10.1021/nl071641w
Huang SCJ, Artyukhin AB, Martinez JA, Sirbuly DJ, Wang Y, Ju JW et al. Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires. Nano Letters. 2007 Nov;7(11):3355-3359. https://doi.org/10.1021/nl071641w
Huang, Shih Chieh J ; Artyukhin, Alexander B. ; Martinez, Julio A. ; Sirbuly, Donald J. ; Wang, Yinmin ; Ju, Jiann Wen ; Stroeve, Pieter ; Noy, Aleksandr. / Formation, stability, and mobility of one-dimensional lipid bilayers on polysilicon nanowires. In: Nano Letters. 2007 ; Vol. 7, No. 11. pp. 3355-3359.
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