Formation of chiral morphologies through selective binding of amino acids to calcite surface steps

C. A. Orme, Aleksandr Noy, A. Wierzbicki, M. T. Mcbride, M. Grantham, H. H. Teng, P. M. Dove, J. J. Deyoreo

Research output: Contribution to journalArticle

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Abstract

Many living organisms contain biominerals and composites with finely tuned properties, reflecting a remarkable level of control over the nucleation, growth and shape of the constituent crystals. Peptides and proteins play an important role in achieving this control. But the general view that organic molecules affect mineralization through stereochemical recognition, where geometrical and chemical constraints dictate their binding to a mineral, seems difficult to reconcile with a mechanistic understanding, where crystallization is controlled by thermodynamic and kinetic factors. Indeed, traditional crystal growth models emphasize the inhibiting effect of so-called 'modifiers' on surface-step growth, rather than stereochemical matching to newly expressed crystal facets. Here we report in situ atomic force microscope observations and molecular modelling studies of calcite growth in the presence of chiral amino acids that reconcile these two seemingly divergent views. We find that enantiomer-specific binding of the amino acids to those surface-step edges that offer the best geometric and chemical fit changes the step-edge 775-779 free energies, which in turn results in macroscopic crystal shape modifications. Our results emphasize that the mechanism underlying crystal modification through organic molecules is best understood by considering both stereochemical recognition and the effects of binding on the interfacial energies of the growing crystal.

Original languageEnglish (US)
Pages (from-to)775-779
Number of pages5
JournalNature
Volume411
Issue number6839
DOIs
StatePublished - Jun 14 2001
Externally publishedYes

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Calcium Carbonate
Crystallization
Amino Acids
Growth
Thermodynamics
Minerals
Peptides
Proteins

ASJC Scopus subject areas

  • General

Cite this

Orme, C. A., Noy, A., Wierzbicki, A., Mcbride, M. T., Grantham, M., Teng, H. H., ... Deyoreo, J. J. (2001). Formation of chiral morphologies through selective binding of amino acids to calcite surface steps. Nature, 411(6839), 775-779. https://doi.org/10.1038/35081034

Formation of chiral morphologies through selective binding of amino acids to calcite surface steps. / Orme, C. A.; Noy, Aleksandr; Wierzbicki, A.; Mcbride, M. T.; Grantham, M.; Teng, H. H.; Dove, P. M.; Deyoreo, J. J.

In: Nature, Vol. 411, No. 6839, 14.06.2001, p. 775-779.

Research output: Contribution to journalArticle

Orme, CA, Noy, A, Wierzbicki, A, Mcbride, MT, Grantham, M, Teng, HH, Dove, PM & Deyoreo, JJ 2001, 'Formation of chiral morphologies through selective binding of amino acids to calcite surface steps', Nature, vol. 411, no. 6839, pp. 775-779. https://doi.org/10.1038/35081034
Orme CA, Noy A, Wierzbicki A, Mcbride MT, Grantham M, Teng HH et al. Formation of chiral morphologies through selective binding of amino acids to calcite surface steps. Nature. 2001 Jun 14;411(6839):775-779. https://doi.org/10.1038/35081034
Orme, C. A. ; Noy, Aleksandr ; Wierzbicki, A. ; Mcbride, M. T. ; Grantham, M. ; Teng, H. H. ; Dove, P. M. ; Deyoreo, J. J. / Formation of chiral morphologies through selective binding of amino acids to calcite surface steps. In: Nature. 2001 ; Vol. 411, No. 6839. pp. 775-779.
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