Force deficit of vascularized skeletal muscle grafts in rabbits

H. W. Burton, Thomas R Stevenson, T. P. White, J. Hartman, J. A. Faulkner

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Through autografting experiments on 9-g rectus femoris (RFM) muscles in rabbits, we substantiated a previous observation that the maximum isometric tetanic force (P0) and specific P0 (N/cm2) of neurovascular-intact grafts are not different from grafts made with neurovascular repair. We then tested the hypotheses that the specific P0 of vascularized grafts is significantly less than that of control RFM muscles and the deficit in the specific P0 is associated with increases in connective tissue and interstitial space. The specific P0 of the grafts was 65% of the value for control RFM muscles. Connective tissue protein concentration of grafts was 3.8 times greater than the control value of 16.6 ± 3 μg/mg wt mass, but this only accounted for a 5% correction in specific P0. The volume of interstitial space did not differ between grafts and control muscles. We conclude that the deficit of 35% in specific P0 of vascularized grafts compared with control values is partially explained by an increase in connective tissue, but a 30% unresolved deficit remains.

Original languageEnglish (US)
Pages (from-to)675-679
Number of pages5
JournalJournal of Applied Physiology
Volume66
Issue number2
StatePublished - 1989
Externally publishedYes

Fingerprint

Skeletal Muscle
Rabbits
Transplants
Quadriceps Muscle
Connective Tissue
Muscles
Autologous Transplantation
Observation
Proteins

ASJC Scopus subject areas

  • Endocrinology
  • Physiology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Burton, H. W., Stevenson, T. R., White, T. P., Hartman, J., & Faulkner, J. A. (1989). Force deficit of vascularized skeletal muscle grafts in rabbits. Journal of Applied Physiology, 66(2), 675-679.

Force deficit of vascularized skeletal muscle grafts in rabbits. / Burton, H. W.; Stevenson, Thomas R; White, T. P.; Hartman, J.; Faulkner, J. A.

In: Journal of Applied Physiology, Vol. 66, No. 2, 1989, p. 675-679.

Research output: Contribution to journalArticle

Burton, HW, Stevenson, TR, White, TP, Hartman, J & Faulkner, JA 1989, 'Force deficit of vascularized skeletal muscle grafts in rabbits', Journal of Applied Physiology, vol. 66, no. 2, pp. 675-679.
Burton, H. W. ; Stevenson, Thomas R ; White, T. P. ; Hartman, J. ; Faulkner, J. A. / Force deficit of vascularized skeletal muscle grafts in rabbits. In: Journal of Applied Physiology. 1989 ; Vol. 66, No. 2. pp. 675-679.
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