Through autografting experiments on 9-g rectus femoris (RFM) muscles in rabbits, we substantiated a previous observation that the maximum isometric tetanic force (P0) and specific P0 (N/cm2) of neurovascular-intact grafts are not different from grafts made with neurovascular repair. We then tested the hypotheses that the specific P0 of vascularized grafts is significantly less than that of control RFM muscles and the deficit in the specific P0 is associated with increases in connective tissue and interstitial space. The specific P0 of the grafts was 65% of the value for control RFM muscles. Connective tissue protein concentration of grafts was 3.8 times greater than the control value of 16.6 ± 3 μg/mg wt mass, but this only accounted for a 5% correction in specific P0. The volume of interstitial space did not differ between grafts and control muscles. We conclude that the deficit of 35% in specific P0 of vascularized grafts compared with control values is partially explained by an increase in connective tissue, but a 30% unresolved deficit remains.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Applied Physiology|
|State||Published - 1989|
ASJC Scopus subject areas
- Orthopedics and Sports Medicine
- Physical Therapy, Sports Therapy and Rehabilitation