Food intake in rhesus monkeys following central administration of orexins

Jon J Ramsey, Joseph W. Kemnitz, Wendy Newton, Kevork Hagopian, Terrell A. Patterson, Andrew G. Swick

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Orexin A has been reported to stimulate food intake in rats while orexin B does not. The purpose of this study was to determine the role of orexin A or orexin B administration on food intake in adult, male rhesus monkeys. Food intake was measured at 2 and 8 h after the morning feeding following central injections of vehicle, orexin A (10, or 20 μg) or orexin B (10, 30, or 100 μg). When compared to vehicle injections, the 10 and 20 μg doses of orexin A decreased food intake at 2 h post-dose by 45% and 64%, respectively. Eight-hour food intake was decreased at only the 20 μg orexin A dose. Orexin B at all doses and time points did not alter food intake when compared to vehicle. These results indicate that orexin A exhibits anorectic activity while orexin B does not affect food intake in the rhesus monkey.

Original languageEnglish (US)
Pages (from-to)209-214
Number of pages6
JournalRegulatory Peptides
Volume124
Issue number1-3
DOIs
StatePublished - Jan 15 2005

    Fingerprint

Keywords

  • Neuropeptide Y
  • Obesity
  • Orexin A
  • Orexin B

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Physiology
  • Neuroscience(all)

Cite this