Following cancer prevention guidelines reduces risk of cancer, cardiovascular disease, and all-cause mortality

Marjorie L. McCullough, Alpa V. Patel, Lawrence H. Kushi, Roshni Patel, Walter C. Willett, Colleen Doyle, Michael J. Thun, Susan M. Gapstur

Research output: Contribution to journalArticle

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Abstract

Background: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on cancer, cardiovascular disease (CVD) and all-cause mortality, and most included tobacco avoidance. Because 80% of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. Methods: In 1992 and 1993, 111,966 nonsmoking men and women in the Cancer Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American Cancer Society cancer prevention guidelines on body mass index, physical activity, diet, and alcohol consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of death and 95% CI were computed by Cox proportional hazard regression. Results: During 14 years of follow-up, 10,369 men and 6,613 women died. The RR of all-cause mortality was lower for participants with high (7, 8) versus low (0-2) scores (men, RR=0.58, 95% CI: 0.53-0.62; women, RR = 0.58, 95% CI: 0.52-0.64). Inverse associations were found with CVD mortality (men, RR = 0.52, 95% CI: 0.45-0.59; women, RR = 0.42, 95% CI: 0.35-0.51) and cancer mortality (men, RR = 0.70, 95% CI: 0.61-0.80; women, RR = 0.76, 95% CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. Conclusion: Adherence to cancer prevention guidelines for obesity, diet, physical activity, and alcohol consumption is associated with lower risk of death from cancer, CVD, and all causes in nonsmokers. Impact: Beyond tobacco avoidance, following other cancer prevention guidelines may substantially lower risk of premature mortality in older adults.

Original languageEnglish (US)
Pages (from-to)1089-1097
Number of pages9
JournalCancer Epidemiology Biomarkers and Prevention
Volume20
Issue number6
DOIs
StatePublished - Jun 2011
Externally publishedYes

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Cardiovascular Diseases
Guidelines
Mortality
Neoplasms
Diet
Alcohol Drinking
Tobacco
Life Style
Exercise
Premature Mortality
Body Mass Index
Obesity

ASJC Scopus subject areas

  • Epidemiology
  • Oncology

Cite this

McCullough, M. L., Patel, A. V., Kushi, L. H., Patel, R., Willett, W. C., Doyle, C., ... Gapstur, S. M. (2011). Following cancer prevention guidelines reduces risk of cancer, cardiovascular disease, and all-cause mortality. Cancer Epidemiology Biomarkers and Prevention, 20(6), 1089-1097. https://doi.org/10.1158/1055-9965.EPI-10-1173

Following cancer prevention guidelines reduces risk of cancer, cardiovascular disease, and all-cause mortality. / McCullough, Marjorie L.; Patel, Alpa V.; Kushi, Lawrence H.; Patel, Roshni; Willett, Walter C.; Doyle, Colleen; Thun, Michael J.; Gapstur, Susan M.

In: Cancer Epidemiology Biomarkers and Prevention, Vol. 20, No. 6, 06.2011, p. 1089-1097.

Research output: Contribution to journalArticle

McCullough, ML, Patel, AV, Kushi, LH, Patel, R, Willett, WC, Doyle, C, Thun, MJ & Gapstur, SM 2011, 'Following cancer prevention guidelines reduces risk of cancer, cardiovascular disease, and all-cause mortality', Cancer Epidemiology Biomarkers and Prevention, vol. 20, no. 6, pp. 1089-1097. https://doi.org/10.1158/1055-9965.EPI-10-1173
McCullough, Marjorie L. ; Patel, Alpa V. ; Kushi, Lawrence H. ; Patel, Roshni ; Willett, Walter C. ; Doyle, Colleen ; Thun, Michael J. ; Gapstur, Susan M. / Following cancer prevention guidelines reduces risk of cancer, cardiovascular disease, and all-cause mortality. In: Cancer Epidemiology Biomarkers and Prevention. 2011 ; Vol. 20, No. 6. pp. 1089-1097.
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abstract = "Background: Few studies have evaluated the combined impact of following recommended lifestyle behaviors on cancer, cardiovascular disease (CVD) and all-cause mortality, and most included tobacco avoidance. Because 80{\%} of Americans are never or former smokers, it is important to consider the impact of other recommended behaviors. Methods: In 1992 and 1993, 111,966 nonsmoking men and women in the Cancer Prevention Study-II Nutrition Cohort completed diet and lifestyle questionnaires. A score ranging from 0 to 8 points was computed to reflect adherence to the American Cancer Society cancer prevention guidelines on body mass index, physical activity, diet, and alcohol consumption, with 8 points representing optimal adherence. Multivariable-adjusted relative risks (RR) of death and 95{\%} CI were computed by Cox proportional hazard regression. Results: During 14 years of follow-up, 10,369 men and 6,613 women died. The RR of all-cause mortality was lower for participants with high (7, 8) versus low (0-2) scores (men, RR=0.58, 95{\%} CI: 0.53-0.62; women, RR = 0.58, 95{\%} CI: 0.52-0.64). Inverse associations were found with CVD mortality (men, RR = 0.52, 95{\%} CI: 0.45-0.59; women, RR = 0.42, 95{\%} CI: 0.35-0.51) and cancer mortality (men, RR = 0.70, 95{\%} CI: 0.61-0.80; women, RR = 0.76, 95{\%} CI: 0.65-0.89). Similar associations, albeit not all statistically significant, were observed for never and former smokers. Conclusion: Adherence to cancer prevention guidelines for obesity, diet, physical activity, and alcohol consumption is associated with lower risk of death from cancer, CVD, and all causes in nonsmokers. Impact: Beyond tobacco avoidance, following other cancer prevention guidelines may substantially lower risk of premature mortality in older adults.",
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AU - Willett, Walter C.

AU - Doyle, Colleen

AU - Thun, Michael J.

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