Abstract
Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo-and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH-and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.
| Original language | English (US) |
|---|---|
| Article number | 242 |
| Journal | Pharmaceutics |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| State | Published - May 1 2019 |
| Externally published | Yes |
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Keywords
- Black phosphorus
- Cancer targeted therapy
- Drug delivery
- Photothermal therapy
- Quantum dots
ASJC Scopus subject areas
- Pharmaceutical Science
Cite this
Folic acid-functionalized black phosphorus quantum dots for targeted chemo-photothermal combination cancer therapy. / Luo, Miaomiao; Cheng, Wei; Zeng, Xiaowei; Mei, Lin; Liu, Gan; Deng, Wenbin.
In: Pharmaceutics, Vol. 11, No. 5, 242, 01.05.2019.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Folic acid-functionalized black phosphorus quantum dots for targeted chemo-photothermal combination cancer therapy
AU - Luo, Miaomiao
AU - Cheng, Wei
AU - Zeng, Xiaowei
AU - Mei, Lin
AU - Liu, Gan
AU - Deng, Wenbin
PY - 2019/5/1
Y1 - 2019/5/1
N2 - Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo-and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH-and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.
AB - Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo-and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH-and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.
KW - Black phosphorus
KW - Cancer targeted therapy
KW - Drug delivery
KW - Photothermal therapy
KW - Quantum dots
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U2 - 10.3390/pharmaceutics11050242
DO - 10.3390/pharmaceutics11050242
M3 - Article
VL - 11
JO - Pharmaceutics
JF - Pharmaceutics
SN - 1999-4923
IS - 5
M1 - 242
ER -