Folic acid-functionalized black phosphorus quantum dots for targeted chemo-photothermal combination cancer therapy

Miaomiao Luo, Wei Cheng, Xiaowei Zeng, Lin Mei, Gan Liu, Wenbin Deng

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo-and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH-and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.

Original languageEnglish (US)
Article number242
JournalPharmaceutics
Volume11
Issue number5
DOIs
StatePublished - May 1 2019
Externally publishedYes

Keywords

  • Black phosphorus
  • Cancer targeted therapy
  • Drug delivery
  • Photothermal therapy
  • Quantum dots

ASJC Scopus subject areas

  • Pharmaceutical Science

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