Folic acid-functionalized black phosphorus quantum dots for targeted chemo-photothermal combination cancer therapy

Miaomiao Luo, Wei Cheng, Xiaowei Zeng, Lin Mei, Gan Liu, Wenbin Deng

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Due to the inherent limitations, single chemo or photothermal therapies (PTT) are always inefficient. The combination of chemotherapy and PTT for the treatment of cancers has attracted a great interest during the past few years. As a photothermal agent, black phosphorus quantum dots (BPQDs) possess an excellent extinction coefficient, high photothermal conversion efficacy, and good biocompatibility. Herein, we developed a photo-and pH-sensitive nanoparticle based on BPQDs for targeted chemo-photothermal therapy. Doxorubicin (DOX) was employed as a model drug. This nanosystem displayed outstanding photothermal performance both in vitro and in vivo. Folic acid conjugation onto the surface endowed this system an excellent tumor-targeting effect, which was demonstrated by the cellular targeting assay. The BPQDs-based drug delivery system exhibited pH-and photo-responsive release properties, which could reduce the potential damage to normal cells. The in vitro cell viability study showed a synergistic effect in suppressing cancer cell proliferation. Therefore, this BPQDs-based drug delivery system has substantial potential for future clinical applications.

Original languageEnglish (US)
Article number242
JournalPharmaceutics
Volume11
Issue number5
DOIs
StatePublished - May 1 2019
Externally publishedYes

Keywords

  • Black phosphorus
  • Cancer targeted therapy
  • Drug delivery
  • Photothermal therapy
  • Quantum dots

ASJC Scopus subject areas

  • Pharmaceutical Science

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