Folate, alcohol, and liver disease

Valentina Medici, Charles H. Halsted

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Alcoholic liver disease (ALD) is typically associated with folate deficiency, which is the result of reduced dietary folate intake, intestinal malabsorption, reduced liver uptake and storage, and increased urinary folate excretion. Folate deficiency favors the progression of liver disease through mechanisms that include its effects on methionine metabolism with consequences for DNA synthesis and stability and the epigenetic regulation of gene expression involved in pathways of liver injury. This paper reviews the pathogenesis of ALD with particular focus on ethanol-induced alterations in methionine metabolism, which may act in synergy with folate deficiency to decrease antioxidant defense as well as DNA stability while regulating epigenetic mechanisms of relevant gene expressions. We also review the current evidence available on potential treatments of ALD based on correcting abnormalities in methionine metabolism and the methylation regulation of relevant gene expressions.

Original languageEnglish (US)
Pages (from-to)596-606
Number of pages11
JournalMolecular Nutrition and Food Research
Volume57
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Alcohol
  • Folate
  • Liver
  • Methionine

ASJC Scopus subject areas

  • Food Science
  • Biotechnology

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