Focus on fenoldopam: A dopaminergic agonist for severe hypertension

M. A. Munger, E. J. Stanek, Edward A Panacek

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Fenoldopam mesylate is a parenteral post-synaptic dopamine1 receptor agonist currently under FDA review for the treatment of severe hypertension. The agent markedly lowers blood pressure, augments renal blood flow secondary to a reduction in renal vascular resistance, and induces both a diuresis and natriuresis in severe hypertensive patients. Fenoldopam exhibits equivalent blood pressure control and dose-response to nitroprusside. Fenoldopam is relatively well tolerated, devoid of toxic metabolite formation, and requires no protection from light. In consideration of its physiological, clinical, and pharmaceutical advantages, fenoldopam would appear to be a useful addition to the antihypertensive armamentarium.

Original languageEnglish (US)
Pages (from-to)453-460
Number of pages8
JournalHospital Formulary
Issue number6
StatePublished - 1991
Externally publishedYes

ASJC Scopus subject areas

  • Pharmaceutical Science


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