Abstract
Dystonia is a rare neurologic disorder of the basal ganglia presenting with involuntary twisting or turning spasm of muscles. Movements localized to the face, eyes, or neck generally present during late adulthood. Cranial dystonia is usually idiopathic but may be caused by trauma or medications. Of 148 patients with focal dystonia referred to Indiana University over four years, four women had the onset of face and neck symptoms eight days to 34 months after completing treatment with chemotherapy alone or combined with radiation therapy. Two patients were treated with 5-FU, one received doxorubicin and one was treated with both. Both drugs have been associated with transient parkinsonism, but no chemotherapeutic medications have been reported to cause dystonia. Three patients remain free of demonstrable malignancy. A possible association of chemotherapy and focal dystonia has not been previously described.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 163-167 |
| Number of pages | 5 |
| Journal | Journal of Neuro-Oncology |
| Volume | 34 |
| Issue number | 2 |
| DOIs | |
| State | Published - Jul 10 1997 |
| Externally published | Yes |
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Keywords
- Cancer
- Chemotherapy
- Dystonia
- Movement disorder
- Neurotoxicity
- Parkinsonism
ASJC Scopus subject areas
- Oncology
- Neurology
- Clinical Neurology
- Cancer Research
Cite this
Focal dystonia after chemotherapy : A case series. / Brashear, A.; Siemers, E.
In: Journal of Neuro-Oncology, Vol. 34, No. 2, 10.07.1997, p. 163-167.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Focal dystonia after chemotherapy
T2 - A case series
AU - Brashear, A.
AU - Siemers, E.
PY - 1997/7/10
Y1 - 1997/7/10
N2 - Dystonia is a rare neurologic disorder of the basal ganglia presenting with involuntary twisting or turning spasm of muscles. Movements localized to the face, eyes, or neck generally present during late adulthood. Cranial dystonia is usually idiopathic but may be caused by trauma or medications. Of 148 patients with focal dystonia referred to Indiana University over four years, four women had the onset of face and neck symptoms eight days to 34 months after completing treatment with chemotherapy alone or combined with radiation therapy. Two patients were treated with 5-FU, one received doxorubicin and one was treated with both. Both drugs have been associated with transient parkinsonism, but no chemotherapeutic medications have been reported to cause dystonia. Three patients remain free of demonstrable malignancy. A possible association of chemotherapy and focal dystonia has not been previously described.
AB - Dystonia is a rare neurologic disorder of the basal ganglia presenting with involuntary twisting or turning spasm of muscles. Movements localized to the face, eyes, or neck generally present during late adulthood. Cranial dystonia is usually idiopathic but may be caused by trauma or medications. Of 148 patients with focal dystonia referred to Indiana University over four years, four women had the onset of face and neck symptoms eight days to 34 months after completing treatment with chemotherapy alone or combined with radiation therapy. Two patients were treated with 5-FU, one received doxorubicin and one was treated with both. Both drugs have been associated with transient parkinsonism, but no chemotherapeutic medications have been reported to cause dystonia. Three patients remain free of demonstrable malignancy. A possible association of chemotherapy and focal dystonia has not been previously described.
KW - Cancer
KW - Chemotherapy
KW - Dystonia
KW - Movement disorder
KW - Neurotoxicity
KW - Parkinsonism
UR - http://www.scopus.com/inward/record.url?scp=0031008863&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031008863&partnerID=8YFLogxK
U2 - 10.1023/A:1005791623733
DO - 10.1023/A:1005791623733
M3 - Article
C2 - 9210064
AN - SCOPUS:0031008863
VL - 34
SP - 163
EP - 167
JO - Journal of Neuro-Oncology
JF - Journal of Neuro-Oncology
SN - 0167-594X
IS - 2
ER -