Focal Alzheimer's disease

William J. Jagust, Peter Davies, Janice K. Tiller-Borcich, Bruce R Reed

Research output: Contribution to journalArticlepeer-review

88 Scopus citations


Alzheimer's disease is characterized by relative sparing of primary sensory and motor cortex and a lack of sensory or motor symptomatology. We report a case of presenile onset dementia accompanied by a slowly progressive hemiparesis. Autopsy examination showed severe pathologic involvement of somatosensory cortex with neuritic plaques and neurofibrillary tangles, in addition to degeneration of the nucleus basalis and locus ceruleus. Neurochemical and immunocytochemical studies showed a moderate cortical cholinergic deficiency with normal somatostatin-like immunoreactivity and a profuse immunostaining of somatosensory cortex with the Alz-50 antibody. These unusual features emphasize that Alzheimer's disease is extremely variable in its clinical symptomatology, pathologic distribution, and neurochemical dimensions.

Original languageEnglish (US)
Pages (from-to)14-19
Number of pages6
Issue number1
StatePublished - Jan 1990
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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