Focal adhesions: What's new inside

Research output: Contribution to journalArticle

121 Scopus citations

Abstract

The cytoplasmic side of focal adhesions is comprised of large molecular complexes that link transmembrane receptors, such as integrins, to the actin cytoskeleton and mediate signals modulating cell attachment, migration, proliferation, differentiation, and gene expression. These complexes are heterogeneous and dynamic structures that are apparent targets of regulatory signals that control the function of focal adhesions. Recent studies using genetic approaches in invertebrate and vertebrate systems have begun to reveal the structure and function of these complexes in vivo.

Original languageEnglish (US)
Pages (from-to)280-291
Number of pages12
JournalDevelopmental Biology
Volume294
Issue number2
DOIs
StatePublished - Jun 15 2006

Keywords

  • Cartilage
  • Focal adhesion
  • Knockout mouse
  • Mutant fly

ASJC Scopus subject areas

  • Developmental Biology

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