Flurothyl seizure susceptibility in rats following prenatal methylazoxymethanol treatment

Scott C. Baraban, Philip A Schwartzkroin

Research output: Contribution to journalArticle

75 Scopus citations

Abstract

Methylazoxymethanol acetate (MAMac) is a potent teratogenic agent which can produce ectopic cell placement in developing rat brains. In the present study, we evaluated (i) whether prenatal exposure to MAMac results in a lowered seizure threshold to flurothyl and (ii) if there is a correlation between the number of ectopic cells in MAMac-exposed hippocampus and flurothyl-induced seizure latency. In 60 day old (P60) rats exposed to MAMac in utero, the latencies to myoclonic jerk (173 ± 2.3 s) and forelimb clonus (215 ± 4.6 s) were significantly shorter than those of controls (200 ± 6.9 s and 238 ± 8.8 s, respectively). MAMac also increased the proportion of flurothyl-treated rats that progressed from bilateral forelimb clonus to generalized tonic-clonic seizures (control: 33%; MAMac: 91%). Shorter seizure latencies were associated with an increased number of ectopic pyramidal cells in region CA1/CA2. These results suggest seizure susceptibility is enhanced in an animal model (MAMac) characterized by abnormal neuronal migration.

Original languageEnglish (US)
Pages (from-to)189-194
Number of pages6
JournalEpilepsy Research
Volume23
Issue number3
DOIs
StatePublished - Apr 1996
Externally publishedYes

Keywords

  • ectopic
  • flurothyl
  • hippocampus
  • rat
  • seizure

ASJC Scopus subject areas

  • Clinical Neurology
  • Pediatrics, Perinatology, and Child Health
  • Neurology

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