Fluorine-19 NMR imaging of glucose metabolism

T. Nakada, I. L. Kwee, P. J. Card, N. A. Matwiyoff, B. V. Griffey, R. H. Griffey

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Abstract

Metabolic imaging reflecting glucose metabolism in the glycolytic and aldose reductase sorbitol (ARS) pathways was performed noninvasively in rat using fluorinated glucose analogs, 2-fluoro-2-deoxy-D-glucose (2-FDG) or 3-fluoro-3-deoxy-D-glucose (3-FDG), and fluorine-19 (19F) nuclear magnetic resonance (NMR) imaging. 19F images of 2-FDG-6-phosphate, a main metabolite of 2-FDG in the glycolytic pathway, showed high glucose utilization in the brain, spinal cord, and heart. Images of 3-fluoro-3-deoxy-D-sorbitol (3-FDSL), a main metabolite of 3-FDG in the ARS pathway, demonstrated the heterogeneous nature of the spatial distribution of aldose reductase activities, being highest in the brain and lens. The extremely low toxicity of 3-FDG indicates promise for clinical application of 3-FDG NMR imaging.

Original languageEnglish (US)
Pages (from-to)307-313
Number of pages7
JournalMagnetic Resonance in Medicine
Volume6
Issue number3
StatePublished - 1988

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ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Nakada, T., Kwee, I. L., Card, P. J., Matwiyoff, N. A., Griffey, B. V., & Griffey, R. H. (1988). Fluorine-19 NMR imaging of glucose metabolism. Magnetic Resonance in Medicine, 6(3), 307-313.