Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Laura Marcu, P. Thomas Vernier, H. Charles Manning, Sarah Salemi, Aimin Li, Cheryl M. Craft, Martin A. Gundersen, Darryl J. Bornhop

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.A. Wagnieres
Pages64-69
Number of pages6
Volume5141
StatePublished - 2003
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Other

OtherDiagnostic Optical Spectroscopy in Biomedicine II
CountryGermany
CityMunich
Period6/24/036/25/03

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Keywords

  • Brain tumors diagnosis
  • Fluorescence microscopy
  • Lanthanide chelates fluorescence
  • Multi-modal imaging probes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Marcu, L., Vernier, P. T., Manning, H. C., Salemi, S., Li, A., Craft, C. M., Gundersen, M. A., & Bornhop, D. J. (2003). Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging. In G. A. Wagnieres (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5141, pp. 64-69)