Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging

Laura Marcu, P. Thomas Vernier, H. Charles Manning, Sarah Salemi, Aimin Li, Cheryl M. Craft, Martin A. Gundersen, Darryl J. Bornhop

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This study investigates the potential of a new multi-modal lanthanide chelate complex for specifically targeting brain tumor cells. We report here results from ongoing studies of up-take, sub-cellular localization and binding specificity of this new molecular imaging probe. Fluorescence microscopy investigations in living rat C6 glioma tumor cells demonstrate that the new imaging agent has affinity for glioma cells and binds to mitochondria.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
EditorsG.A. Wagnieres
Pages64-69
Number of pages6
Volume5141
StatePublished - 2003
EventDiagnostic Optical Spectroscopy in Biomedicine II - Munich, Germany
Duration: Jun 24 2003Jun 25 2003

Other

OtherDiagnostic Optical Spectroscopy in Biomedicine II
CountryGermany
CityMunich
Period6/24/036/25/03

Fingerprint

Fluorescence microscopy
brain
Tumors
Brain
tumors
Cells
microscopy
Molecular imaging
Imaging techniques
fluorescence
Mitochondria
mitochondria
probes
Rare earth elements
chelates
rats
affinity
Rats
cells

Keywords

  • Brain tumors diagnosis
  • Fluorescence microscopy
  • Lanthanide chelates fluorescence
  • Multi-modal imaging probes

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Marcu, L., Vernier, P. T., Manning, H. C., Salemi, S., Li, A., Craft, C. M., ... Bornhop, D. J. (2003). Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging. In G. A. Wagnieres (Ed.), Proceedings of SPIE - The International Society for Optical Engineering (Vol. 5141, pp. 64-69)

Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging. / Marcu, Laura; Vernier, P. Thomas; Manning, H. Charles; Salemi, Sarah; Li, Aimin; Craft, Cheryl M.; Gundersen, Martin A.; Bornhop, Darryl J.

Proceedings of SPIE - The International Society for Optical Engineering. ed. / G.A. Wagnieres. Vol. 5141 2003. p. 64-69.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Marcu, L, Vernier, PT, Manning, HC, Salemi, S, Li, A, Craft, CM, Gundersen, MA & Bornhop, DJ 2003, Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging. in GA Wagnieres (ed.), Proceedings of SPIE - The International Society for Optical Engineering. vol. 5141, pp. 64-69, Diagnostic Optical Spectroscopy in Biomedicine II, Munich, Germany, 6/24/03.
Marcu L, Vernier PT, Manning HC, Salemi S, Li A, Craft CM et al. Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging. In Wagnieres GA, editor, Proceedings of SPIE - The International Society for Optical Engineering. Vol. 5141. 2003. p. 64-69
Marcu, Laura ; Vernier, P. Thomas ; Manning, H. Charles ; Salemi, Sarah ; Li, Aimin ; Craft, Cheryl M. ; Gundersen, Martin A. ; Bornhop, Darryl J. / Fluorescence microscopy studies of a peripheral benzodiazepine receptor targeted molecular probe for brain tumor imaging. Proceedings of SPIE - The International Society for Optical Engineering. editor / G.A. Wagnieres. Vol. 5141 2003. pp. 64-69
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