Abstract
Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.
| Original language | English (US) |
|---|---|
| Title of host publication | Fluorescence Lifetime Spectroscopy and Imaging |
| Subtitle of host publication | Principles and Applications in Biomedical Diagnostics |
| Publisher | CRC Press |
| Pages | 399-421 |
| Number of pages | 23 |
| ISBN (Electronic) | 9781439861684 |
| ISBN (Print) | 9781439861677 |
| DOIs | |
| State | Published - Jan 1 2014 |
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ASJC Scopus subject areas
- Engineering(all)
- Physics and Astronomy(all)
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Fluorescence lifetime techniques in cardiovascular disease diagnostics. / Phipps, Jennifer E.; Sun, Yang; Marcu, Laura.
Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. CRC Press, 2014. p. 399-421.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Fluorescence lifetime techniques in cardiovascular disease diagnostics
AU - Phipps, Jennifer E.
AU - Sun, Yang
AU - Marcu, Laura
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.
AB - Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.
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U2 - 10.1201/b17018
DO - 10.1201/b17018
M3 - Chapter
SN - 9781439861677
SP - 399
EP - 421
BT - Fluorescence Lifetime Spectroscopy and Imaging
PB - CRC Press
ER -