Fluorescence lifetime techniques in cardiovascular disease diagnostics

Jennifer E. Phipps, Yang Sun, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.

Original languageEnglish (US)
Title of host publicationFluorescence Lifetime Spectroscopy and Imaging
Subtitle of host publicationPrinciples and Applications in Biomedical Diagnostics
PublisherCRC Press
Pages399-421
Number of pages23
ISBN (Electronic)9781439861684
ISBN (Print)9781439861677
DOIs
StatePublished - Jan 1 2014

Fingerprint

Rupture
Cardiovascular Diseases
Fluorescence
life (durability)
fluorescence
coronary artery disease
arteriosclerosis
Cholesterol
cholesterol
Atherosclerotic Plaques
Acute Coronary Syndrome
arteries
Developed Countries
death
imaging techniques
Lipids
attack
blood
lipids
Coronary Artery Disease

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)
  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Phipps, J. E., Sun, Y., & Marcu, L. (2014). Fluorescence lifetime techniques in cardiovascular disease diagnostics. In Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics (pp. 399-421). CRC Press. https://doi.org/10.1201/b17018

Fluorescence lifetime techniques in cardiovascular disease diagnostics. / Phipps, Jennifer E.; Sun, Yang; Marcu, Laura.

Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. CRC Press, 2014. p. 399-421.

Research output: Chapter in Book/Report/Conference proceedingChapter

Phipps, JE, Sun, Y & Marcu, L 2014, Fluorescence lifetime techniques in cardiovascular disease diagnostics. in Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. CRC Press, pp. 399-421. https://doi.org/10.1201/b17018
Phipps JE, Sun Y, Marcu L. Fluorescence lifetime techniques in cardiovascular disease diagnostics. In Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. CRC Press. 2014. p. 399-421 https://doi.org/10.1201/b17018
Phipps, Jennifer E. ; Sun, Yang ; Marcu, Laura. / Fluorescence lifetime techniques in cardiovascular disease diagnostics. Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics. CRC Press, 2014. pp. 399-421
@inbook{dc594b433cbc4af6bad1e21e34027806,
title = "Fluorescence lifetime techniques in cardiovascular disease diagnostics",
abstract = "Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.",
author = "Phipps, {Jennifer E.} and Yang Sun and Laura Marcu",
year = "2014",
month = "1",
day = "1",
doi = "10.1201/b17018",
language = "English (US)",
isbn = "9781439861677",
pages = "399--421",
booktitle = "Fluorescence Lifetime Spectroscopy and Imaging",
publisher = "CRC Press",

}

TY - CHAP

T1 - Fluorescence lifetime techniques in cardiovascular disease diagnostics

AU - Phipps, Jennifer E.

AU - Sun, Yang

AU - Marcu, Laura

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.

AB - Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.

UR - http://www.scopus.com/inward/record.url?scp=85055210371&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85055210371&partnerID=8YFLogxK

U2 - 10.1201/b17018

DO - 10.1201/b17018

M3 - Chapter

SN - 9781439861677

SP - 399

EP - 421

BT - Fluorescence Lifetime Spectroscopy and Imaging

PB - CRC Press

ER -