Fluorescence lifetime techniques in cardiovascular disease diagnostics

Jennifer E. Phipps, Yang Sun, Laura Marcu

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Cardiovascular disease has long been the number one cause of death and morbidity for adults in developed countries (Roger et al. 2010). Coronary artery disease is the most common type of cardiovascular disease and is caused by the development of atherosclerotic plaques in the coronary arteries of the heart; plaque is composed of lipids, cholesterol, calcium, and other types of cells found circulating in the blood stream (Ross 1993). Heart attack and other acute coronary syndromes are caused by plaque rupture, and although there are oftentimes no precluding physical symptoms to this phenomenon, plaques with a higher risk of rupture are morphologically different than their more stable counterparts and are deemed high-risk or “vulnerable plaques” (Libby 2002; Virmani et al. 2000). There is currently no method clinically available for assessing risk of plaque rupture; thus, many research efforts are being expended to develop imaging techniques for this purpose. This chapter presents a review of the time-resolved fluorescence techniques applied to characterization and diagnosis of atherosclerosis.

Original languageEnglish (US)
Title of host publicationFluorescence Lifetime Spectroscopy and Imaging
Subtitle of host publicationPrinciples and Applications in Biomedical Diagnostics
PublisherCRC Press
Pages399-421
Number of pages23
ISBN (Electronic)9781439861684
ISBN (Print)9781439861677
DOIs
StatePublished - Jan 1 2014

ASJC Scopus subject areas

  • Engineering(all)
  • Physics and Astronomy(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Phipps, J. E., Sun, Y., & Marcu, L. (2014). Fluorescence lifetime techniques in cardiovascular disease diagnostics. In Fluorescence Lifetime Spectroscopy and Imaging: Principles and Applications in Biomedical Diagnostics (pp. 399-421). CRC Press. https://doi.org/10.1201/b17018