Fluorescence lifetime spectroscopy and imaging in neurosurgery

Laura Marcu, Brad A. Hartl

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.

Original languageEnglish (US)
Article number6138897
Pages (from-to)1465-1477
Number of pages13
JournalIEEE Journal on Selected Topics in Quantum Electronics
Volume18
Issue number4
DOIs
StatePublished - 2012

Fingerprint

Neurosurgery
brain
Brain
Fluorescence
Spectroscopy
Imaging techniques
Tumors
life (durability)
fluorescence
tumors
spectroscopy
surgery
Surgery
emerging
methodology
Tissue

Keywords

  • Autofluorescence
  • brain tumor
  • fluorescence
  • glioma
  • imaging
  • neurosurgery
  • spectroscopy
  • surgery

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics

Cite this

Fluorescence lifetime spectroscopy and imaging in neurosurgery. / Marcu, Laura; Hartl, Brad A.

In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 18, No. 4, 6138897, 2012, p. 1465-1477.

Research output: Contribution to journalArticle

@article{a324bfac880e4ae69a64fb0201741573,
title = "Fluorescence lifetime spectroscopy and imaging in neurosurgery",
abstract = "Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.",
keywords = "Autofluorescence, brain tumor, fluorescence, glioma, imaging, neurosurgery, spectroscopy, surgery",
author = "Laura Marcu and Hartl, {Brad A.}",
year = "2012",
doi = "10.1109/JSTQE.2012.2185823",
language = "English (US)",
volume = "18",
pages = "1465--1477",
journal = "IEEE Journal of Selected Topics in Quantum Electronics",
issn = "1077-260X",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
number = "4",

}

TY - JOUR

T1 - Fluorescence lifetime spectroscopy and imaging in neurosurgery

AU - Marcu, Laura

AU - Hartl, Brad A.

PY - 2012

Y1 - 2012

N2 - Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.

AB - Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.

KW - Autofluorescence

KW - brain tumor

KW - fluorescence

KW - glioma

KW - imaging

KW - neurosurgery

KW - spectroscopy

KW - surgery

UR - http://www.scopus.com/inward/record.url?scp=84863947235&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863947235&partnerID=8YFLogxK

U2 - 10.1109/JSTQE.2012.2185823

DO - 10.1109/JSTQE.2012.2185823

M3 - Article

VL - 18

SP - 1465

EP - 1477

JO - IEEE Journal of Selected Topics in Quantum Electronics

JF - IEEE Journal of Selected Topics in Quantum Electronics

SN - 1077-260X

IS - 4

M1 - 6138897

ER -