Fluorescence lifetime spectroscopy and imaging in neurosurgery

Laura Marcu, Brad A. Hartl

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.

Original languageEnglish (US)
Article number6138897
Pages (from-to)1465-1477
Number of pages13
JournalIEEE Journal on Selected Topics in Quantum Electronics
Issue number4
StatePublished - 2012


  • Autofluorescence
  • brain tumor
  • fluorescence
  • glioma
  • imaging
  • neurosurgery
  • spectroscopy
  • surgery

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Atomic and Molecular Physics, and Optics


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