Abstract
Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.
| Original language | English (US) |
|---|---|
| Article number | 6138897 |
| Pages (from-to) | 1465-1477 |
| Number of pages | 13 |
| Journal | IEEE Journal on Selected Topics in Quantum Electronics |
| Volume | 18 |
| Issue number | 4 |
| DOIs | |
| State | Published - 2012 |
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Keywords
- Autofluorescence
- brain tumor
- fluorescence
- glioma
- imaging
- neurosurgery
- spectroscopy
- surgery
ASJC Scopus subject areas
- Electrical and Electronic Engineering
- Atomic and Molecular Physics, and Optics
Cite this
Fluorescence lifetime spectroscopy and imaging in neurosurgery. / Marcu, Laura; Hartl, Brad A.
In: IEEE Journal on Selected Topics in Quantum Electronics, Vol. 18, No. 4, 6138897, 2012, p. 1465-1477.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluorescence lifetime spectroscopy and imaging in neurosurgery
AU - Marcu, Laura
AU - Hartl, Brad A.
PY - 2012
Y1 - 2012
N2 - Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.
AB - Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.
KW - Autofluorescence
KW - brain tumor
KW - fluorescence
KW - glioma
KW - imaging
KW - neurosurgery
KW - spectroscopy
KW - surgery
UR - http://www.scopus.com/inward/record.url?scp=84863947235&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863947235&partnerID=8YFLogxK
U2 - 10.1109/JSTQE.2012.2185823
DO - 10.1109/JSTQE.2012.2185823
M3 - Article
AN - SCOPUS:84863947235
VL - 18
SP - 1465
EP - 1477
JO - IEEE Journal of Selected Topics in Quantum Electronics
JF - IEEE Journal of Selected Topics in Quantum Electronics
SN - 1077-260X
IS - 4
M1 - 6138897
ER -