Fluorescence lifetime in cardiovascular diagnostics

Laura Marcu

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.

Original languageEnglish (US)
Article number011106
JournalJournal of Biomedical Optics
Volume15
Issue number1
DOIs
StatePublished - 2010

Keywords

  • Atherosclerotic plaques
  • Fluorescence lifetime imaging microscopy (FLIM)
  • Fluorescence lifetime spectroscopy
  • Intravascular ultrasound

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics

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