Abstract
We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
| Original language | English (US) |
|---|---|
| Article number | 011106 |
| Journal | Journal of Biomedical Optics |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2010 |
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Keywords
- Atherosclerotic plaques
- Fluorescence lifetime imaging microscopy (FLIM)
- Fluorescence lifetime spectroscopy
- Intravascular ultrasound
ASJC Scopus subject areas
- Biomedical Engineering
- Biomaterials
- Electronic, Optical and Magnetic Materials
- Atomic and Molecular Physics, and Optics
Cite this
Fluorescence lifetime in cardiovascular diagnostics. / Marcu, Laura.
In: Journal of Biomedical Optics, Vol. 15, No. 1, 011106, 2010.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluorescence lifetime in cardiovascular diagnostics
AU - Marcu, Laura
PY - 2010
Y1 - 2010
N2 - We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
AB - We review fluorescence lifetime techniques including timeresolved laser-induced fluorescence spectroscopy (TR-LIFS) and fluorescence lifetime imaging microscopy (FLIM) instrumentation and associated methodologies that allow for characterization and diagnosis of atherosclerotic plaques. Emphasis is placed on the translational research potential of TR-LIFS and FLIM and on determining whether intrinsic fluorescence signals can be used to provide useful contrast for the diagnosis of high-risk atherosclerotic plaque. Our results demonstrate that these techniques allow for the discrimination of important biochemical features involved in atherosclerotic plaque instability and rupture and show their potential for future intravascular applications.
KW - Atherosclerotic plaques
KW - Fluorescence lifetime imaging microscopy (FLIM)
KW - Fluorescence lifetime spectroscopy
KW - Intravascular ultrasound
UR - http://www.scopus.com/inward/record.url?scp=77953160347&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953160347&partnerID=8YFLogxK
U2 - 10.1117/1.3327279
DO - 10.1117/1.3327279
M3 - Article
C2 - 20210432
AN - SCOPUS:77953160347
VL - 15
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
SN - 1083-3668
IS - 1
M1 - 011106
ER -