Abstract
Airway epithelia possess transepithelial ion transport processes which may help to regulate the fluid content of airway secretions. Chloride secretion promotes fluid movement from blood to airway lumen. Active absorption of Na favours fluid movement in the opposite direction. The balance between these two processes can be altered by a number of agents which stimulate Cl secretion. The importance of ion transport for normal mucociliary clearance is suggested by the finding that airway epithelia in patients with cystic fibrosis are unable to secrete chloride. This defect may cause the characteristically sticky and tenacious mucous secretions which are the major cause of death in this disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 551-555 |
| Number of pages | 5 |
| Journal | Biorheology |
| Volume | 24 |
| Issue number | 6 |
| State | Published - 1987 |
| Externally published | Yes |
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Keywords
- chloride secretion
- fluid transport
- mucociliary clearance
ASJC Scopus subject areas
- Medicine(all)
Cite this
Fluid transport by airway epithelia. / Widdicombe, Jonathan.
In: Biorheology, Vol. 24, No. 6, 1987, p. 551-555.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluid transport by airway epithelia
AU - Widdicombe, Jonathan
PY - 1987
Y1 - 1987
N2 - Airway epithelia possess transepithelial ion transport processes which may help to regulate the fluid content of airway secretions. Chloride secretion promotes fluid movement from blood to airway lumen. Active absorption of Na favours fluid movement in the opposite direction. The balance between these two processes can be altered by a number of agents which stimulate Cl secretion. The importance of ion transport for normal mucociliary clearance is suggested by the finding that airway epithelia in patients with cystic fibrosis are unable to secrete chloride. This defect may cause the characteristically sticky and tenacious mucous secretions which are the major cause of death in this disease.
AB - Airway epithelia possess transepithelial ion transport processes which may help to regulate the fluid content of airway secretions. Chloride secretion promotes fluid movement from blood to airway lumen. Active absorption of Na favours fluid movement in the opposite direction. The balance between these two processes can be altered by a number of agents which stimulate Cl secretion. The importance of ion transport for normal mucociliary clearance is suggested by the finding that airway epithelia in patients with cystic fibrosis are unable to secrete chloride. This defect may cause the characteristically sticky and tenacious mucous secretions which are the major cause of death in this disease.
KW - chloride secretion
KW - fluid transport
KW - mucociliary clearance
UR - http://www.scopus.com/inward/record.url?scp=0023610210&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0023610210&partnerID=8YFLogxK
M3 - Article
C2 - 3332079
AN - SCOPUS:0023610210
VL - 24
SP - 551
EP - 555
JO - Biorheology
JF - Biorheology
SN - 0006-355X
IS - 6
ER -