Fluid transport by airway epithelia

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Abstract

Airway epithelia possess transepithelial ion transport processes which may help to regulate the fluid content of airway secretions. Chloride secretion promotes fluid movement from blood to airway lumen. Active absorption of Na favours fluid movement in the opposite direction. The balance between these two processes can be altered by a number of agents which stimulate Cl secretion. The importance of ion transport for normal mucociliary clearance is suggested by the finding that airway epithelia in patients with cystic fibrosis are unable to secrete chloride. This defect may cause the characteristically sticky and tenacious mucous secretions which are the major cause of death in this disease.

Original languageEnglish (US)
Pages (from-to)551-555
Number of pages5
JournalBiorheology
Volume24
Issue number6
StatePublished - 1987
Externally publishedYes

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Keywords

  • chloride secretion
  • fluid transport
  • mucociliary clearance

ASJC Scopus subject areas

  • Medicine(all)

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