Abstract
Active ion transport across the surface epithelium of dog trachea results in fluid transport. The direction and amount of fluid transported may depend on a balance between active chloride secretion and active sodium absorption. In contrast, fluid movement across submucosal gland epithelium does not seem to depend on active salt transport. Instead, water may be drawn into the duct lumen by simple osmosis after the release of the osmotically active contents of secretory granules. Cell culture may provide a means of studying the secretory properties of the individual cell types of airway epithelia. We have produced primary monolayer cultures of cells from dog tracheal epithelium which retain the differentiated salt and water transport of the original tissue.
| Original language | English (US) |
|---|---|
| Title of host publication | Mucus and Mucosa |
| Publisher | John Wiley and Sons Ltd. |
| Pages | 109-120 |
| Number of pages | 12 |
| ISBN (Electronic) | 9780470720905 |
| ISBN (Print) | 0272797839, 9780272797839 |
| DOIs | |
| State | Published - May 30 2008 |
| Externally published | Yes |
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Keywords
- Active chloride secretion
- Active ion transport
- Airway epithelia
- Fluid transport
- Surface epithelium
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
Cite this
Fluid Transport Across Airway Epithelia. / Widdicombe, Jonathan.
Mucus and Mucosa. John Wiley and Sons Ltd., 2008. p. 109-120.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Fluid Transport Across Airway Epithelia
AU - Widdicombe, Jonathan
PY - 2008/5/30
Y1 - 2008/5/30
N2 - Active ion transport across the surface epithelium of dog trachea results in fluid transport. The direction and amount of fluid transported may depend on a balance between active chloride secretion and active sodium absorption. In contrast, fluid movement across submucosal gland epithelium does not seem to depend on active salt transport. Instead, water may be drawn into the duct lumen by simple osmosis after the release of the osmotically active contents of secretory granules. Cell culture may provide a means of studying the secretory properties of the individual cell types of airway epithelia. We have produced primary monolayer cultures of cells from dog tracheal epithelium which retain the differentiated salt and water transport of the original tissue.
AB - Active ion transport across the surface epithelium of dog trachea results in fluid transport. The direction and amount of fluid transported may depend on a balance between active chloride secretion and active sodium absorption. In contrast, fluid movement across submucosal gland epithelium does not seem to depend on active salt transport. Instead, water may be drawn into the duct lumen by simple osmosis after the release of the osmotically active contents of secretory granules. Cell culture may provide a means of studying the secretory properties of the individual cell types of airway epithelia. We have produced primary monolayer cultures of cells from dog tracheal epithelium which retain the differentiated salt and water transport of the original tissue.
KW - Active chloride secretion
KW - Active ion transport
KW - Airway epithelia
KW - Fluid transport
KW - Surface epithelium
UR - http://www.scopus.com/inward/record.url?scp=84954597698&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84954597698&partnerID=8YFLogxK
U2 - 10.1002/9780470720905.ch8
DO - 10.1002/9780470720905.ch8
M3 - Chapter
AN - SCOPUS:84954597698
SN - 0272797839
SN - 9780272797839
SP - 109
EP - 120
BT - Mucus and Mucosa
PB - John Wiley and Sons Ltd.
ER -