Fluid Transport Across Airway Epithelia

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Active ion transport across the surface epithelium of dog trachea results in fluid transport. The direction and amount of fluid transported may depend on a balance between active chloride secretion and active sodium absorption. In contrast, fluid movement across submucosal gland epithelium does not seem to depend on active salt transport. Instead, water may be drawn into the duct lumen by simple osmosis after the release of the osmotically active contents of secretory granules. Cell culture may provide a means of studying the secretory properties of the individual cell types of airway epithelia. We have produced primary monolayer cultures of cells from dog tracheal epithelium which retain the differentiated salt and water transport of the original tissue.

Original languageEnglish (US)
Title of host publicationMucus and Mucosa
PublisherJohn Wiley and Sons Ltd.
Pages109-120
Number of pages12
ISBN (Electronic)9780470720905
ISBN (Print)0272797839, 9780272797839
DOIs
StatePublished - May 30 2008
Externally publishedYes

Keywords

  • Active chloride secretion
  • Active ion transport
  • Airway epithelia
  • Fluid transport
  • Surface epithelium

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Widdicombe, J. (2008). Fluid Transport Across Airway Epithelia. In Mucus and Mucosa (pp. 109-120). John Wiley and Sons Ltd.. https://doi.org/10.1002/9780470720905.ch8