Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure

Pedro Boscan, Bruno H Pypendop, Kristine T. Siao, Thierry Francey, Kristy Dowers, Larry D Cowgill, Jan Ilkiw

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objective - To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure. Animals - 23 dogs treated with a tibial plateau leveling osteotomy. Procedures - 12 dogs were used as a control group. Cardiac output was measured in 5 dogs, and 6 dogs received carprofen for at least 14 days. Dogs received oxymorphone, atropine, propofol, and isoflurane for anesthesia (duration, 4 hours). Urine and blood samples were obtained for analysis every 30 minutes. Lactated Ringer's solution was administered at 10 mL/kg/h. Urine output was measured and glomerular filtration rate was estimated. Fluid retention was measured by use of body weight, fluid balance, and bioimpedance spectroscopy. Results - No difference was found among control, cardiac output, or carprofen groups, so data were combined. Median urine output and glomerular filtration rate were 0.46 mL/kg/h and 1.84 mL/kg/min. Dogs retained a large amount of fluids during anesthesia, as indicated by increased body weight, positive fluid balance, increased total body water volume, and increased extracellular fluid volume. The PCV, total protein concentration, and esophageal temperature decreased in a linear manner. Conclusions and Clinical Relevance - Dogs anesthetized for a tibial plateau leveling osteotomy retained a large amount of fluids, had low urinary output, and had decreased PCV, total protein concentration, and esophageal temperature. Evaluation of urine output alone in anesthetized dogs may not be an adequate indicator of fluid balance.

Original languageEnglish (US)
Pages (from-to)501-507
Number of pages7
JournalAmerican Journal of Veterinary Research
Volume71
Issue number5
DOIs
StatePublished - May 2010

Fingerprint

Orthopedic Procedures
Water-Electrolyte Balance
glomerular filtration rate
orthopedics
Glomerular Filtration Rate
urine
surgery
Urine
Dogs
dogs
cardiac output
Osteotomy
Cardiac Output
anesthesia
plateaus
Oxymorphone
Anesthesia
Body Weight
fluids
Temperature

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure. / Boscan, Pedro; Pypendop, Bruno H; Siao, Kristine T.; Francey, Thierry; Dowers, Kristy; Cowgill, Larry D; Ilkiw, Jan.

In: American Journal of Veterinary Research, Vol. 71, No. 5, 05.2010, p. 501-507.

Research output: Contribution to journalArticle

@article{ae36ff0b95664a5e9544f58a11a74c12,
title = "Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure",
abstract = "Objective - To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure. Animals - 23 dogs treated with a tibial plateau leveling osteotomy. Procedures - 12 dogs were used as a control group. Cardiac output was measured in 5 dogs, and 6 dogs received carprofen for at least 14 days. Dogs received oxymorphone, atropine, propofol, and isoflurane for anesthesia (duration, 4 hours). Urine and blood samples were obtained for analysis every 30 minutes. Lactated Ringer's solution was administered at 10 mL/kg/h. Urine output was measured and glomerular filtration rate was estimated. Fluid retention was measured by use of body weight, fluid balance, and bioimpedance spectroscopy. Results - No difference was found among control, cardiac output, or carprofen groups, so data were combined. Median urine output and glomerular filtration rate were 0.46 mL/kg/h and 1.84 mL/kg/min. Dogs retained a large amount of fluids during anesthesia, as indicated by increased body weight, positive fluid balance, increased total body water volume, and increased extracellular fluid volume. The PCV, total protein concentration, and esophageal temperature decreased in a linear manner. Conclusions and Clinical Relevance - Dogs anesthetized for a tibial plateau leveling osteotomy retained a large amount of fluids, had low urinary output, and had decreased PCV, total protein concentration, and esophageal temperature. Evaluation of urine output alone in anesthetized dogs may not be an adequate indicator of fluid balance.",
author = "Pedro Boscan and Pypendop, {Bruno H} and Siao, {Kristine T.} and Thierry Francey and Kristy Dowers and Cowgill, {Larry D} and Jan Ilkiw",
year = "2010",
month = "5",
doi = "10.2460/ajvr.71.5.501",
language = "English (US)",
volume = "71",
pages = "501--507",
journal = "American Journal of Veterinary Research",
issn = "0002-9645",
publisher = "American Veterinary Medical Association",
number = "5",

}

TY - JOUR

T1 - Fluid balance, glomerular filtration rate, and urine output in dogs anesthetized for an orthopedic surgical procedure

AU - Boscan, Pedro

AU - Pypendop, Bruno H

AU - Siao, Kristine T.

AU - Francey, Thierry

AU - Dowers, Kristy

AU - Cowgill, Larry D

AU - Ilkiw, Jan

PY - 2010/5

Y1 - 2010/5

N2 - Objective - To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure. Animals - 23 dogs treated with a tibial plateau leveling osteotomy. Procedures - 12 dogs were used as a control group. Cardiac output was measured in 5 dogs, and 6 dogs received carprofen for at least 14 days. Dogs received oxymorphone, atropine, propofol, and isoflurane for anesthesia (duration, 4 hours). Urine and blood samples were obtained for analysis every 30 minutes. Lactated Ringer's solution was administered at 10 mL/kg/h. Urine output was measured and glomerular filtration rate was estimated. Fluid retention was measured by use of body weight, fluid balance, and bioimpedance spectroscopy. Results - No difference was found among control, cardiac output, or carprofen groups, so data were combined. Median urine output and glomerular filtration rate were 0.46 mL/kg/h and 1.84 mL/kg/min. Dogs retained a large amount of fluids during anesthesia, as indicated by increased body weight, positive fluid balance, increased total body water volume, and increased extracellular fluid volume. The PCV, total protein concentration, and esophageal temperature decreased in a linear manner. Conclusions and Clinical Relevance - Dogs anesthetized for a tibial plateau leveling osteotomy retained a large amount of fluids, had low urinary output, and had decreased PCV, total protein concentration, and esophageal temperature. Evaluation of urine output alone in anesthetized dogs may not be an adequate indicator of fluid balance.

AB - Objective - To determine fluid retention, glomerular filtration rate, and urine output in dogs anesthetized for a surgical orthopedic procedure. Animals - 23 dogs treated with a tibial plateau leveling osteotomy. Procedures - 12 dogs were used as a control group. Cardiac output was measured in 5 dogs, and 6 dogs received carprofen for at least 14 days. Dogs received oxymorphone, atropine, propofol, and isoflurane for anesthesia (duration, 4 hours). Urine and blood samples were obtained for analysis every 30 minutes. Lactated Ringer's solution was administered at 10 mL/kg/h. Urine output was measured and glomerular filtration rate was estimated. Fluid retention was measured by use of body weight, fluid balance, and bioimpedance spectroscopy. Results - No difference was found among control, cardiac output, or carprofen groups, so data were combined. Median urine output and glomerular filtration rate were 0.46 mL/kg/h and 1.84 mL/kg/min. Dogs retained a large amount of fluids during anesthesia, as indicated by increased body weight, positive fluid balance, increased total body water volume, and increased extracellular fluid volume. The PCV, total protein concentration, and esophageal temperature decreased in a linear manner. Conclusions and Clinical Relevance - Dogs anesthetized for a tibial plateau leveling osteotomy retained a large amount of fluids, had low urinary output, and had decreased PCV, total protein concentration, and esophageal temperature. Evaluation of urine output alone in anesthetized dogs may not be an adequate indicator of fluid balance.

UR - http://www.scopus.com/inward/record.url?scp=77953077605&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77953077605&partnerID=8YFLogxK

U2 - 10.2460/ajvr.71.5.501

DO - 10.2460/ajvr.71.5.501

M3 - Article

VL - 71

SP - 501

EP - 507

JO - American Journal of Veterinary Research

JF - American Journal of Veterinary Research

SN - 0002-9645

IS - 5

ER -