Fluid and electrolyte secretion in the inflamed gut: Novel targets for treatment of inflammation-induced diarrhea

Melanie Gareau, Kim E. Barrett

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Diarrheal disease can occur in the context of both inflammatory and infectious challenges. Inflammation can result in changes in ion transporter expression or simply mislocalization of the protein. In addition to development of diarrhea, an altered secretory state can lead to changes in mucus secretion and luminal pH. Bacterial infection can lead to subversion of host cell signaling, leading to transporter mislocalization and hyposecretion, promoting bacterial colonization. Novel therapeutic strategies are currently being developed to ameliorate transporter defects in the setting of inflammation or bacterial infection including, for example, administration of probiotics and fecal microbiota transplantation. This review will highlight recent findings in the literature detailing these aspects of ion transport in the inflamed gut.

Original languageEnglish (US)
Pages (from-to)895-899
Number of pages5
JournalCurrent Opinion in Pharmacology
Volume13
Issue number6
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology

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