Flor-Essence® herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats

L. Michelle Bennett, Jennifer L. Montgomery, Seth M. Steinberg, Kristen S. Kulp

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence ® tonic is a complex mixture of herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. Methods: Female Sprague-Dawley rats were given water or exposed to 3 or 6% Flor-Essence ® beginning at 1 day of age. Mammary tumors were induced with a single oral 40 mg/kg/bw dose of dimethyl-benz[a]anthracene at 50 days of age and sacrificed at 23 weeks. Rats were maintained on AIN-76A diet. Results: Control rats had palpable mammary tumor incidence of 51.0% at 19 weeks of age compared to 65.0 and 59.4% for the 3 and 6% Flor-Essence ® groups respectively. Overall, no significant difference in time until first palpable tumor was detected among any of the groups. At necropsy, mammary tumor incidence was 82.5% for controls compared to 90.0 and 97.3% for rats consuming 3 and 6% Flor-Essence ®, respectively. Mean mammary tumor multiplicity (±SES) for the controls was 2.8 (±0.5) and statistically different from the 3 or 6% Flor-Essence ® groups with 5.2 (±0.7), and 4.8 (±0.6), respectively (p £ 0.01). As expected, the majority of isolated tumors were diagnosed as adenocarcinomas. Conclusions: Flor-Essence ® can promote mammary tumor development in the Sprague-Dawley rat model. This observation is contrary to widely available anecdotal evidence as well as the desire of the consumer that this commercially available herbal tonic will suppress and/or inhibit tumor growth.

Original languageEnglish (US)
Pages (from-to)87-93
Number of pages7
JournalBreast Cancer Research and Treatment
Volume88
Issue number1
DOIs
StatePublished - Nov 2004
Externally publishedYes

Fingerprint

Sprague Dawley Rats
Breast Neoplasms
Complementary Therapies
Neoplasms
Incidence
Complex Mixtures
flor-essence
Adenocarcinoma
Diet
Recurrence
Water
Health
Growth

Keywords

  • complementary and alternative medicine
  • DMBA tumors
  • herbal tonic
  • mammary tumors
  • Sprague-Dawley rat model

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Flor-Essence® herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats. / Michelle Bennett, L.; Montgomery, Jennifer L.; Steinberg, Seth M.; Kulp, Kristen S.

In: Breast Cancer Research and Treatment, Vol. 88, No. 1, 11.2004, p. 87-93.

Research output: Contribution to journalArticle

Michelle Bennett, L. ; Montgomery, Jennifer L. ; Steinberg, Seth M. ; Kulp, Kristen S. / Flor-Essence® herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats. In: Breast Cancer Research and Treatment. 2004 ; Vol. 88, No. 1. pp. 87-93.
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title = "Flor-Essence{\circledR} herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats",
abstract = "Background: Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence {\circledR} tonic is a complex mixture of herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. Methods: Female Sprague-Dawley rats were given water or exposed to 3 or 6{\%} Flor-Essence {\circledR} beginning at 1 day of age. Mammary tumors were induced with a single oral 40 mg/kg/bw dose of dimethyl-benz[a]anthracene at 50 days of age and sacrificed at 23 weeks. Rats were maintained on AIN-76A diet. Results: Control rats had palpable mammary tumor incidence of 51.0{\%} at 19 weeks of age compared to 65.0 and 59.4{\%} for the 3 and 6{\%} Flor-Essence {\circledR} groups respectively. Overall, no significant difference in time until first palpable tumor was detected among any of the groups. At necropsy, mammary tumor incidence was 82.5{\%} for controls compared to 90.0 and 97.3{\%} for rats consuming 3 and 6{\%} Flor-Essence {\circledR}, respectively. Mean mammary tumor multiplicity (±SES) for the controls was 2.8 (±0.5) and statistically different from the 3 or 6{\%} Flor-Essence {\circledR} groups with 5.2 (±0.7), and 4.8 (±0.6), respectively (p £ 0.01). As expected, the majority of isolated tumors were diagnosed as adenocarcinomas. Conclusions: Flor-Essence {\circledR} can promote mammary tumor development in the Sprague-Dawley rat model. This observation is contrary to widely available anecdotal evidence as well as the desire of the consumer that this commercially available herbal tonic will suppress and/or inhibit tumor growth.",
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T1 - Flor-Essence® herbal tonic does not inhibit mammary tumor development in Sprague Dawley rats

AU - Michelle Bennett, L.

AU - Montgomery, Jennifer L.

AU - Steinberg, Seth M.

AU - Kulp, Kristen S.

PY - 2004/11

Y1 - 2004/11

N2 - Background: Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence ® tonic is a complex mixture of herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. Methods: Female Sprague-Dawley rats were given water or exposed to 3 or 6% Flor-Essence ® beginning at 1 day of age. Mammary tumors were induced with a single oral 40 mg/kg/bw dose of dimethyl-benz[a]anthracene at 50 days of age and sacrificed at 23 weeks. Rats were maintained on AIN-76A diet. Results: Control rats had palpable mammary tumor incidence of 51.0% at 19 weeks of age compared to 65.0 and 59.4% for the 3 and 6% Flor-Essence ® groups respectively. Overall, no significant difference in time until first palpable tumor was detected among any of the groups. At necropsy, mammary tumor incidence was 82.5% for controls compared to 90.0 and 97.3% for rats consuming 3 and 6% Flor-Essence ®, respectively. Mean mammary tumor multiplicity (±SES) for the controls was 2.8 (±0.5) and statistically different from the 3 or 6% Flor-Essence ® groups with 5.2 (±0.7), and 4.8 (±0.6), respectively (p £ 0.01). As expected, the majority of isolated tumors were diagnosed as adenocarcinomas. Conclusions: Flor-Essence ® can promote mammary tumor development in the Sprague-Dawley rat model. This observation is contrary to widely available anecdotal evidence as well as the desire of the consumer that this commercially available herbal tonic will suppress and/or inhibit tumor growth.

AB - Background: Women who are diagnosed with breast cancer often self-administer complementary and alternative medicines to augment their conventional treatments, improve health, or prevent recurrence. Flor-Essence ® tonic is a complex mixture of herbal extracts used by cancer patients because of anecdotal evidence that it can treat or prevent disease. Methods: Female Sprague-Dawley rats were given water or exposed to 3 or 6% Flor-Essence ® beginning at 1 day of age. Mammary tumors were induced with a single oral 40 mg/kg/bw dose of dimethyl-benz[a]anthracene at 50 days of age and sacrificed at 23 weeks. Rats were maintained on AIN-76A diet. Results: Control rats had palpable mammary tumor incidence of 51.0% at 19 weeks of age compared to 65.0 and 59.4% for the 3 and 6% Flor-Essence ® groups respectively. Overall, no significant difference in time until first palpable tumor was detected among any of the groups. At necropsy, mammary tumor incidence was 82.5% for controls compared to 90.0 and 97.3% for rats consuming 3 and 6% Flor-Essence ®, respectively. Mean mammary tumor multiplicity (±SES) for the controls was 2.8 (±0.5) and statistically different from the 3 or 6% Flor-Essence ® groups with 5.2 (±0.7), and 4.8 (±0.6), respectively (p £ 0.01). As expected, the majority of isolated tumors were diagnosed as adenocarcinomas. Conclusions: Flor-Essence ® can promote mammary tumor development in the Sprague-Dawley rat model. This observation is contrary to widely available anecdotal evidence as well as the desire of the consumer that this commercially available herbal tonic will suppress and/or inhibit tumor growth.

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KW - DMBA tumors

KW - herbal tonic

KW - mammary tumors

KW - Sprague-Dawley rat model

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